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TranscriptomicsTranscription profiling of human fibroblasts subjected to DNA damage reveals ATM-dependent regulation of gene expression
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6971 | biostudies-arrayexpress
TranscriptomicsExpression data from HTR-8/Svneo side population (SP) and non-side population (NSP) cells
Immature cell populations, including stem cells and progenitor cells, can be found in “side-population (SP)” cells. Although SP cells isolated from some adult tissues have been reported elsewhere, isolation and characterization of human trophoblast SP cells remained to be reported. We used microarra...
ORGANISM(S): Homo sapiens 
2011-03-12 | E-GEOD-27909 | biostudies-arrayexpress
TranscriptomicsLoss of Karma transposon methylation underlies oil palm somaclonal mantling
The oil palm fruit abnormality, mantled, is a somaclonal variant arising from tissue culture that drastically reduces yield, and has largely halted efforts to clone elite hybrids for breeding and oil production. Widely regarded as epigenetic, mantling had defied explanation, and has become an icon ...
ORGANISM(S): Elaeis guineensis 
2015-09-09 | E-GEOD-68410 | biostudies-arrayexpress
TranscriptomicsRIP: miR-202 mimic-transfected HeLa cells vs. negative control
Potential miR-202 targets were identified using a targetome-wide RIP-based microarray. HeLa cells were transfected with either a miR-202 mimic or a scrambled single-stranded RNA negative control. RNA was isolated from total cell lysate prior to IP and from antibody-immobilized Protein G agarose be...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42981 | biostudies-arrayexpress
TranscriptomicsGenomic and physiological responses to strong selective pressure during late organogenesis: how natural Fundulus heteroclitus populations cope with persistent environmental pollution Superfund Site
This study explores the synergistic effects of two model PAHs, an aryl hydrocarbon receptor (AHR) agonist (M-NM-2-naphthoflavone) and a cytochrome P4501A (CYP1A) inhibitor (M-NM-1-naphthoflavone), on gene expression in stage 31 embryos from two different population. One population (Elizabeth River ...
ORGANISM(S): Fundulus heteroclitus 
2013-09-30 | E-GEOD-47654 | biostudies-arrayexpress
TranscriptomicsGene expressioin signatures in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes post sham- or IR-treatment
Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes 6h post sham- or 1.5 Gy IR-treatmentl was compared to extract IR-related gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients. Biological replicat...
ORGANISM(S): Homo sapiens 
2013-04-09 | E-GEOD-45849 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fiber cell maturation in the lens
The mammalian lens consists of an aged core of quiescent cells enveloped by a layers of mature fully elongated and younger, continuously elongating and transcriptionaly active cells. In the present study, we compared global gene expression profiles in elongating and mature, non-elongating fiber cell...
ORGANISM(S): Mus musculus 
2008-06-22 | E-GEOD-2083 | biostudies-arrayexpress
TranscriptomicsGene expressioin signatures at basal level in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes
Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes at basal level was compared to extract gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients. Biological replicates: 4; Technical replicates: 2 wi...
ORGANISM(S): Homo sapiens 
2013-04-09 | E-GEOD-45848 | biostudies-arrayexpress
TranscriptomicsA High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells
High doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. Using microarray analysis and Ingenuity Pathways AnalysisTM, we identified genes (up- or down-regulated, M-bM-^IM-%1.5 fold, P M-bM-^IM-$ 0.001), functions and signaling pathways that were altered follo...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-19477 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of constitutively competent comR and proQ mutants and RNase R (rnr) mutant of L. pneumophila
Bacterial competence is a genetically programmed process that is triggered as a response to environmental stimuli. DNA uptake from the extracellular milieu by competence requires the expression of a complex machinery composed of a competence pseudopilus and a DNA translocase. In L. pneumophila, it ...
ORGANISM(S): Legionella pneumophila 
2010-05-20 | E-GEOD-12796 | biostudies-arrayexpress
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