Transcription profiling of human fibroblasts subjected to DNA damage reveals ATM-dependent regulation of gene expression

ABSTRACT: The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA damage checkpoints. Profiles of global gene expression in AT cells were determined at 2, 6 and 24 h after treatment with 1.5 Gy IR or sham-treatment, and were compared to those previously recognized in normal human fibroblasts. Under basal conditions 160 genes or ESTs were differentially expressed in AT and normal fibroblasts, and these were associated by gene ontology with insulin-like growth factor binding and regulation of cell growth. Upon DNA damage, 1091 gene mRNAs were changed in at lea

ORGANISM(S): Homo sapiens

SUBMITTER: Tong Zhou 

PROVIDER: E-GEOD-6971 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress