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UnknownObesity significantly alters the human sperm proteome, with potential implications for fertility.

Purpose

In men, obesity may lead to poor semen parameters and reduced fertility. However, the causative links between obesity and male infertility are not totally clear, particularly on a molecular level. As such, we investigated how obesity modifies the human sperm proteome, to elucidate an...
S-EPMC7183029 | biostudies-literature
UnknownA Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series.
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized exercise intervention. Con...
S-EPMC10975467 | biostudies-literature
UnknownCell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity.
Sister chromatid cohesion (SCC), efficient DNA repair, and the regulation of some metazoan genes require the association of cohesins with chromosomes. Cohesins are deposited by a conserved heterodimeric loading complex composed of the Scc2 and Scc4 proteins in Saccharomyces cerevisiae, but how the S...
S-EPMC4024903 | biostudies-literature
UnknownGenetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude.
Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes to physiological human adaptations to hypoxia, a multifaceted process critical to health and disease. To delve into the molecular underpinnings of this phenomenon, first, we performed a multi-omics analysis of RB...
S-EPMC10769835 | biostudies-literature
ProteomicsEstablishment of Minimum Protein Standards for Mycobacterium tuberculosis-Derived Extracellular Vesicles through Comparison of EV Enrichment Methods
Extracellular vesicles (EVs) produced by Mycobacterium tuberculosis, the causative agent of tuberculosis, are involved in acquiring nutrients, evading host immune mechanisms, and modulating the host immune response. The functions of these M. tuberculosis EVs (MEVs)are hypothesized to be due to the d...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-05-07 | PXD056465 | Pride
Proteomics Mycobacterium tuberculosis Liquid chromatography-mass spectrometry/mass spectrometry Extracellular vesicles Bruker timstof pro 
UnknownHypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and, most importantly, hydrogen peroxide. However, it is unclear whether accumulation of intracellular and supernatant hypoxanthine in stored red blood cell units is clinically relevant for transfused rec...
S-EPMC5792281 | biostudies-literature
UnknownQuantitative Profiling of the Lymph Node Clearance Capacity.
Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome present in ly...
S-EPMC6062610 | biostudies-literature
ProteomicsPerilipin 2 mediates milk fat globule secretion
Analysis of the milk fat globule membrane proteome from mice with genetic deletion of Perilipin 2 (Plin2/ADRP/ADPH)
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD035020 | Pride
Adrp Perilipin 2 Apocrine secretion Lc ms/ms Proteomics Lactation Lipid droplet Adph Mouse Milk fat globule membrane 
ProteomicsChaperone-mediated autophagy sustains hematopoietic stem cell function
Activation of mostly quiescent hematopoietic stem cells (HSC) is a prerequisite for life-long blood production1, 2. This process requires major molecular adaptations to meet the regulatory and metabolic requirements for cell division3-8. The mechanisms governing cellular reprograming upon stem cell ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-05 | PXD022196 | Pride
Autophagy  chaperones  lipid metabolism  lysosomes  protein degradation  protein quality control  stem cells 
UnknownSupernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology.

Background

Laboratory technologies have highlighted the progressive accumulation of the so-called "storage lesion," a wide series of alterations to stored red blood cells (RBCs) that may affect the safety and effectiveness of the transfusion therapy. New improvements in the field are awaited...
S-EPMC5957548 | biostudies-literature
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