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ProteomicsInteractome of E1 ubiquitin-activating enzymes and of E2 ubiquitin-conjugating enzymes in human HEK293 cells.
Investigation of E1 ubiquitin-activating enzymes and E2 ubiquitin-conjugating enzymes interactome in human HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042361 | Pride
E1 ubiquitin-activating enzymes  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells  interactome. 
ProteomicsOrthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
Protein ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2, and ubiquitin ligase E3. Uba1 was thought to be the only E1 until the recent identification of Uba6 as an alternative. To differentiate the biological functions of Uba1 and Uba6, we ap...
ORGANISM(S): Homo sapiens (Human) 
2017-07-31 | PXD005513 | Pride
Lc-msms Ubiquitination Ubiquitin 
UnknownHydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.
Not available
S-EPMC5573600 | biostudies-literature
UnknownA Survey on the Expression of the Ubiquitin Proteasome System Components HECT- and RBR-E3 Ubiquitin Ligases and E2 Ubiquitin-Conjugating and E1 Ubiquitin-Activating Enzymes during Human Brain Development.
Not available
S-EPMC10889685 | biostudies-literature
UnknownCrystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.
Not available
S-EPMC2888440 | biostudies-literature
UnknownImpaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme.
Not available
S-EPMC1621053 | biostudies-literature
TranscriptomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
Ubiquitin-related modifier 1 (Urm1) is an evolutionarily conserved ubiquitin-like protein. In eukaryotes, it serves dual roles as a sulfur donor for tRNA modification and a posttranslational protein modifier. Urm1 is proposed to be a primitive protein modifier and a potential precursor to the more c...
ORGANISM(S): Homo sapiens 
2026-03-23 | GSE305835 | GEO
GenomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
NAE1/UBA3-UBE2M are E1 and E2 Enzymes for the Urm1 Modification in Human Cells
PRJNA1307993 | ENA
UnknownOrthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes.
Not available
S-EPMC5290280 | biostudies-literature
UnknownUbiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.
Not available
S-EPMC2712597 | biostudies-literature
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