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TranscriptomicsTranscriptome profiling of a backcross between experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains to identify expression quantitative trait loci.
The aim of the experiment is to characterize the genetics and mechanisms of the inflammatory response after induction of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, by studying the genome wide expression in the spleen in late disease. A backcross was created betwe...
ORGANISM(S): Rattus norvegicus 
2013-08-10 | E-MTAB-784 | biostudies-arrayexpress
TranscriptomicsGene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
Myelin Basic Protein (MBP) induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, produces an an acute weakness, or paralysis of the tail and hind limb ataxia ,weakness or paralysis associated with increased permiability of the blood brain barrier, inflammation and demyelination i...
ORGANISM(S): Rattus norvegicus 
2013-04-03 | E-GEOD-39119 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse experimental autoimmune encephalomyelitis (EAE) from spinal cord preparations of opticospinal EAE (OSE) and MOG-induced EAE
Genetic opticospinal EAE (OSE) and MOG-induced EAE (MOG-EAE) are two experimental autoimmune encephalomyelitis (EAE) mouse models of human multiple sclerosis. For the OSE model, double-transgenic 2D2 (TCRMOG) x IgHMOG mice were used. For MOG-EAE, wildtype C57BL/6 mice were immunized with a MOG pept...
ORGANISM(S): Mus musculus 
2020-08-21 | E-MTAB-9132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat spinal cord with experimental autoimmune encephalomyelitis at 3 disease points, acute, relapsing and recovering vs. controls
The intention of the study was to examine the spinal cord gene expression at three different EAE disease points and to compare them with three nonimmunised, healthy rats. We immunised female DA rats with recombinant MOG-protein and sacrificed them during the acute phase of EAE defined as the first E...
ORGANISM(S): Rattus norvegicus 
2007-05-15 | E-MEXP-1025 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations induced by AT-EAE in mouse spinal cord
We compared RNA samples extracted from spinal cords of control (C) and AT-EAE (E) mice using the "Multiple Yellow" strategy. 4 distinct C-extracts were hybridized with two slides and 4 distinct E-extracts with other two slides, and the green/red normalized signals were compared separately and the E/...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2446 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, harvested at peak of disease in EAE from CNS [EAE-CNS-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75107 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, harvested at peak of disease in EAE from LN [EAE-LN-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75108 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of Th17 cells, isolated from CNS or LN at peak of disease in EAE
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75105 | biostudies-arrayexpress
GenomicsChlamydia abortus strain:EAE-LX
Chlamydophila abortus EAE-LX genome sequencing
PRJNA289095 | ENA
TranscriptomicsChange of fate comitment in adult neural progenitor cells subjected to chronic inflammation
Neural progenitor cells (NPCs) have regenerative capabilities that are activated during inflammation. By measuring the global transcriptome and performing functional studies, we aimed at elucidating if and how NPCs from the non-germinal niche of the spinal cord differ from germinal niche NPCs, here ...
ORGANISM(S): Rattus norvegicus 
2014-09-09 | E-GEOD-46373 | biostudies-arrayexpress
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