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TranscriptomicsInduced overexpression of Pdx1 and Ngn3 in a mouse ES cell-derived endoderm population induces pancreatic differentiation
Induced overexpression of Pdx1 in activin-induced endoderm population resulted in the upregulation of pancreas-related genes such as insulin 1 and 2 at day 20. To enhance the developmental progression from the pancreatic bud to the formation of the endocrine lineages, we next expressed neurogenin3 ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-23752 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [scRNA-seq]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17228 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
TranscriptomicsImpact of 5-Aza-2`-deoxycytidine and Epigallocatechin-3-gallate for induction of human regulatory T cells
The epigenetic regulation of transcription factor genes is critical for T cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg-specific demethylated region (TSDR), is restricted to regulatory T (Treg)...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-53448 | biostudies-arrayexpress
TranscriptomicsFoxO RNAi in C2C12 cells
C2C12 cells are mouse skeletal muscle cells. These cells were transfected with shRNA against FoxO1, FoxO3, and FoxO4. FoxO1, FoxO3, and FoxO4 are the known paralogues expressed in this cell line. C2C12 cells are transfected with shRNA against FoxO1, FoxO3, and FoxO4, respectively. Colonies were...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-13347 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Bos taurus immature oocytes and 8-cell embryos to assess the impact of the loss of sample representation caused by the use of global linear amplification (T7-IVT) during microarray hybridization sample preparation
Assessing the impact of the loss of sample representation caused by the use of global linear amplification (T7-IVT) during microarray hybridization sample preparation.
ORGANISM(S): Bos taurus 
2009-03-25 | E-MEXP-2099 | biostudies-arrayexpress
TranscriptomicsRNA-seq influenza infected B6 & D2 mice
The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suitable to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilizing a dual RNAseq approach...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-66040 | biostudies-arrayexpress
GenomicsDistinct EMT programs control normal stem cells and cancer stem cells of mammary tissue
Cancer stem cells (CSCs) are proposed to be responsible for metastatic dissemination and clinical relapse in a variety of cancers. Analogies between CSCs and normal tissue stem cells (SC) has led to the notion that CSCs often co-opt the normal SC program of their tissue-of-origin. The cell-biologica...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-61198 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate cancer cell line PC3 cells (low in PURa expression) stably over-expressing PUR reveals aPUR alpha protein induces endoplasmic reticulum stress response and cell differentiation pathways in prostate cancer
Following androgen ablation treatment for advanced prostate cancer, almost all men relapse after a period of initial response to therapy, which eventually is life threatening. We have previously found that purine-rich element binding protein, PUR alpha, was significantly repressed in androgen-indepe...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-14464 | biostudies-arrayexpress
TranscriptomicsTbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex
Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a transcription factor expressed in postmitotic projection neurons, exerts positive and negative control over both...
ORGANISM(S): Mus musculus 
2010-07-27 | E-GEOD-22371 | biostudies-arrayexpress
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