Sort   by:  
 Page size 
TranscriptomicsThe DNA methylation landscape of human early embryos
Our data provided a genome-wide DNA methylation landscape of human early development embryos, including human MII oocytes, sperm, zygotes, 2-cell to 8-cell embryos, morula, blastocyst and postimplantation embryos at single base resolution. In total, 44 samples including biological and technical repl...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-49828 | biostudies-arrayexpress
ProteomicsSingle cell analysis for oocytes and early embryos
While non-mammalian embryos often rely on spatial pre-patterning, for decades it was believed that blastomeres of mouse and human embryos were developmentally equivalent. However, emerging evidence suggests early mouse and human blastomeres differ in developmental potential. Here, using multiplexed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2025-08-10 | MSV000098778 | MassIVE
ModelsTsai2014 - Cell cycle duration control by oscillatory Dynamics in Early Xenopus laevis Embryos
During the early development of Xenopus laevis embryos, the first mitotic cell cycle is long (∼85 min) and the subsequent 11 cycles are short (∼30 min) and clock-like. Here we address the question of how the Cdk1 cell cycle oscillator changes between these two modes of operation. We found that the c...
2024-09-02 | BIOMD0000000719 | BioModels
TranscriptomicsGene expression profiling of individual human oocytes and embryos
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals. Data from assisted reproduction programmes provides additional evidence that this is largely mediated at the level of embryonic ...
ORGANISM(S): Homo sapiens 
2013-12-13 | E-MEXP-3870 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of individual blastomeres of early Ciona embryos
We examined gene expression profiles of individual blastomeres of early Ciona embryos using microarrays. We examined gene expression profiles of individual blastomeres of the 8-cell, 16-cell and 32-cell embryos by dissecting with a fine glass needle. We also examined gene expression profiles of unfe...
ORGANISM(S): Ciona intestinalis 
2013-10-29 | E-GEOD-45548 | biostudies-arrayexpress
TranscriptomicsPiwi proteins and piRNAs in mammalian oocytes and early embryos
Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi-piRNA expression in oocytes of other mammals. Human fetal oocytes express PIWIL2 and transposon-enriched...
ORGANISM(S): Macaca fascicularis 
2015-03-27 | E-GEOD-64942 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of bovine IVF embryos revealed candidate genes and pathways involved in early embryonic development
Using microarrays, genome-wide RNA expression was profiled and compared for in vitro fertilization (IVF) - derived blastocysts and embryos undergoing degenerative development up to the same time point. Surprisingly similar transcriptomic profiles were found in degenerative embryos and blastocysts. N...
ORGANISM(S): Bos taurus 
2010-10-28 | E-GEOD-24936 | biostudies-arrayexpress
TranscriptomicsMaternal and paternal genomes contribute equally to the transcriptome of early plant embryos
In animals, maternal gene products deposited into eggs regulate embryonic development before activation of the zygotic genome. In plants, an analogous period of prolonged maternal control over embryogenesis is thought to occur based on gene-expression studies. However, other gene-expression studies ...
ORGANISM(S): Arabidopsis thaliana 
2012-01-12 | E-GEOD-33713 | biostudies-arrayexpress
MetabolomicsMetabolic Changes of Maternal Uterine Fluid, Uterus, and Plasma during the Peri-implantation Period of Early Pregnancy in Mice
Embryo implantation is a complex process which involves biochemical and physiological interactions between an implantation-competent blastocyst and a receptive uterus. However, the exact biochemical changes of uterine fluid, uterus, and plasma during peri-implantation remain unclear. This study aims...
2020-05-04 | MTBLS627 | MetaboLights
TranscriptomicsTranscription in Pronuclei and One- to Four-Cell Embryos Drives Early Development in a Nematode
A long-standing view of development is that transcription is silenced in the oocyte until early divisions in the embryo. The point at which major transcription is reactivated varies in different organisms, but is usually after the 2-cell stage. However, this model may not be universal. We used RNA-s...
ORGANISM(S): Ascaris suum 
2014-01-02 | E-GEOD-46277 | biostudies-arrayexpress
Sort   by:  
 Page size