Sort   by:  
 Page size 
UnknownSomatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.
Not available
S-EPMC4207878 | biostudies-literature
UnknownValidation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes.
Not available
S-EPMC3438234 | biostudies-literature
TranscriptomicsThe Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS) suggesting that haploinsufficie...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-20352 | biostudies-arrayexpress
TranscriptomicsMouse Dbh-/- vs. Dbh+/+ E10.5 hearts
Genomic microarray analysis of adrenergic-deficient (Dbh-/-) vs. wild-type control (Dbh+/+) mouse heart expression at embryonic day 10.5 (E10.5). Four Dbh-/- and four Dbh+/+ E10.5 hearts were isolated, and RNA was extracted from each for genomic microarray analysis using Affymetrix 430A 2.0 arrays. ...
ORGANISM(S): Mus musculus 
2012-11-06 | E-GEOD-33906 | biostudies-arrayexpress
TranscriptomicsGenome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function [cultured cortical neurons]
To examine potential differences in activity-dependent gene expression, we analyzed mRNA expression in cultured neurons isolated from Wild-type vs MeCP2 S421A mice at 0 (unstimulated), 1 or 6 hours after membrane depolarization by exposure to high extracellular KCl (55mM) All mice were male litterma...
ORGANISM(S): Mus musculus 
2011-09-07 | E-GEOD-31849 | biostudies-arrayexpress
UnknownExtremophile Poeciliidae: multivariate insights into the complexity of speciation along replicated ecological gradients.
Not available
S-EPMC4918007 | biostudies-literature
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
TranscriptomicsmiRNA combined
miRNA expression data for the "MicroRNA expression profiles classify human cancers". Keywords = miRNA Keywords = microRNA Keywords = normal Keywords = tumor Keywords = cell-line Keywords = cancer Keywords: other
ORGANISM(S): Mus musculus 
2005-05-11 | E-GEOD-2564 | biostudies-arrayexpress
GenomicsGenome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function [ChIP-Seq]
Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption o...
ORGANISM(S): Mus musculus 
2011-09-08 | E-GEOD-31951 | biostudies-arrayexpress
Sort   by:  
 Page size