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MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
TranscriptomicsExpression data from Th2 cell of ECM1 KO mice vs WT mice
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-19707 | biostudies-arrayexpress
ProteomicsExtracellular Matrix Protein 1 as a critical mediator of inflammation-to-fibrosis crosstalk in wound healing after myocardial infarction
Aims and introduction: Cardiac fibrosis is the hallmark of cardiac disease, particularly myocardial infarction (MI), and is one of the most prevalent causes of heart failure. MI is intricately linked to inflammation, extracellular matrix (ECM) remodelling, and cardiac fibrosis, however the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027626 | Pride
Ecm1 Adult human cardiac fibroblast (hucfb) cell line Human Cardiac wound healing Extracellular matrix Heart failure (hf) 
GenomicsRNA sequence analysis between ECM1- sufficient and -deficient peritoneal macrophage
RNA sequence analysis between ECM1- sufficient and -deficient peritoneal macrophage
PRJNA590877 | ENA
GenomicsRNA sequencing in ovarian cancer cell line HEYA8 in terms of ECM1 silencing and reintroduction of ECM1 subtypes ECM1a and ECM1b
RNA sequencing in ovarian cancer cell line HEYA8 in terms of ECM1 silencing and reintroduction of ECM1 subtypes ECM1a and ECM1b
PRJNA719542 | ENA
GenomicsTranscriptome Sequencing Analysis of Human Colorectal Cancer Cell Lines After ECM1 Knockdown
Transcriptome Sequencing Analysis of Human Colorectal Cancer Cell Lines After ECM1 Knockdown
PRJNA1398929 | ENA
TranscriptomicsRNA sequence analysis between ECM1- sufficient and -deficient peritoneal macrophage
We report the differential gene expression between ECM1- sufficient and -deficient peritoneal macrophage. Inflammatory bowel disease (IBD) comprises chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Here, we uncov...
ORGANISM(S): Mus musculus 
2019-11-22 | GSE140766 | GEO
TranscriptomicsTranscriptome Sequencing Analysis of Human Colorectal Cancer Cell Lines After ECM1 Knockdown
To investigate the regulatory role of ECM1 in CCL20 expression in colorectal cancer, this study employed the human colorectal cancer SW620 cell line. Stable knockdown of ECM1 gene expression was achieved via shRNA, and single-cell transcriptome sequencing technology was used to systematically compar...
ORGANISM(S): Homo sapiens 
2026-01-11 | GSE315767 | GEO
GenomicsHuman melanoma cells over-express Extracellular Matrix 1 (ECM1) which is regulated in part by TFAP2C
Extracellular Matrix 1(ECM1) expression is increased in multiple tumor cell lines and primary cancers. Activator protein 2C (TFAP2C) is a potent regulator of ECM1 transcription. TFAP2C may contribute to the increased ECM1 expression noted in many cancers. This is the first report identifying the min...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-41234 | biostudies-arrayexpress
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