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TranscriptomicsData integration from two microarray platforms identifies genetic inactivation of RIC8A in a breast cancer cell line
Using array comparative genomic hybridization (aCGH), a large number of deleted genomic regions have been identified in human cancers. However, subsequent efforts to identify target genes selected for inactivation in these regions have often been challenging. We integrated here genome-wide copy numb...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-15477 | biostudies-arrayexpress
TranscriptomicsaCGH of neuroblastic tumors
Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a ...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-18143 | biostudies-arrayexpress
TranscriptomicsIntegrative genomic, transcriptomic and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer.
Background: Castration-resistant prostate cancer (CRPC) represents a therapeutic challenge for current medications. Methods: In order to explore the molecular mechanisms involved in CRPC progression and to identify new therapeutic targets, we analyzed a unique sample set of 11 castration-resistant p...
ORGANISM(S): Homo sapiens 
2011-08-28 | E-GEOD-28403 | biostudies-arrayexpress
TranscriptomicsArray-based gene expression in neuroblastic tumors
Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-18139 | biostudies-arrayexpress
TranscriptomicsDrug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response [Expression profiling]
Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2 signaling pathway, and the molecular mechanisms related to treatment response were sought. To search for response predictors, genomic and transcriptomic prof...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-58700 | biostudies-arrayexpress
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