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UnknownSphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
Not available
S-EPMC2151183 | biostudies-literature
GenomicsA draft map of cis-regulatory sequences in the mouse genome [ChIP-Seq]
As the most widely used mammalian model organism, mice play a critical role in biomedical research for mechanistic study of human development and diseases. Today, functional sequences in the mouse genome are still poorly annotated a decade after its initial sequencing. We report here a map of nearl...
ORGANISM(S): Mus musculus 
2012-07-01 | E-GEOD-29218 | biostudies-arrayexpress
GenomicsDistinct epigenomic landscapes of pluripotent and lineage-committed human cells
Human embryonic stem cells share identical genomic sequences with other lineage-committed cells yet possess the remarkable properties of self-renewal and pluripotency. It has been proposed that epigenetic regulatory mechanisms, involving DNA methylation and various chromatin modifications, are at l...
ORGANISM(S): Homo sapiens 
2009-10-13 | E-GEOD-17917 | biostudies-arrayexpress
GenomicsChromatin States in Human ES Cells Reveal Key Regulatory Sequences and Genes Involved in Pluripotency and Self-renewal
Human embryonic stem cells (hESCs) are offering a new therapeutic approach because of their unique ability to proliferate indefinitely in vitro and differentiate into multiple cell types. However, our understanding of the molecular mechanisms of pluripotency and self-renewal remain incomplete. To el...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-18292 | biostudies-arrayexpress
UnknownA map of the cis-regulatory sequences in the mouse genome.
Not available
S-EPMC4041622 | biostudies-literature
UnknownExome analysis identified a novel mutation in the RBP4 gene in a consanguineous pedigree with retinal dystrophy and developmental abnormalities.
Not available
S-EPMC3506607 | biostudies-literature
UnknownHuman DNA methylomes at base resolution show widespread epigenomic differences.
Not available
S-EPMC2857523 | biostudies-literature
UnknownDistinct epigenomic landscapes of pluripotent and lineage-committed human cells.
Not available
S-EPMC2867844 | biostudies-literature
UnknownIntegrative analysis of haplotype-resolved epigenomes across human tissues.
Not available
S-EPMC4449149 | biostudies-literature
TranscriptomicsIntegrative analysis of haplotype-resolved epigenomes across human tissues
Allelic differences between the two sets of chromosomes can affect the propensity of inheritance in humans, but the extent of such differences in the human genome has yet to be fully explored. Here, we delineate allelic chromatin modifications and transcriptomes amongst a broad set of human tissues...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-58752 | biostudies-arrayexpress
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