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TranscriptomicsENCODE: PolyA+ RNA from retinoic acid stimulated HL-60 cells at 4 time points (NCBIv35)
PolyA+ RNA from retinoic acid stimulated HL-60 cells at 0, 2, 8, or 32 hours using Affymetrix ENCODE tiling chip with NCBI build 35 annotation. PolyA+ RNA from retinoic acid stimulated HL-60 cells at 0, 2, 8, or 32 hours.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-3662 | biostudies-arrayexpress
GenomicsTwo isoforms of Fs(1)h ChIP-seq
ChIP-seq was performed using Drosophila Kc167 cells using antibodies against the two isoforms of Fs(1)h, the Brd4 homologue. Differences in binding patterns between the two isoforms are described. We examined the differences in Fs(1)h isoform binding across the genome and describe the short isoform ...
ORGANISM(S): Drosophila melanogaster 
2012-11-15 | E-GEOD-42086 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of a novel pro-angiogenic small molecule phthalimide neovascular factor 1 (PNF1)
We generated the transcriptional regulatory footprint of phthalimide neovascular factor 1 (PNF1)—a novel synthetic small molecule that exhibits significant in vitro endothelial potency and significant in vivo microvascular network expansion—by performing comparative microarray analysis on PNF1-stimu...
ORGANISM(S): Homo sapiens 
2009-07-17 | E-GEOD-17119 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SupT1 cells 6 to 60 hours after HHV-6B infection without inhibitors
Transcriptional profiling of viral genes.
ORGANISM(S): Homo sapiens 
2010-04-05 | E-MEXP-2129 | biostudies-arrayexpress
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
TranscriptomicsComparison of genomic, morphological, and behavioral responses among fathead minnow (Pimephales promelas ) and zebrafish (Danio rerio) to acute RDX exposure
Paper Abstract. Extrapolating toxicological sensitivity information across species can require the use of highly conservative safety factors as prescribed by ecological risk assessment protocols. The objective of our study was to use multipule factors to understand the dynamics of stress responses ...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-27067 | biostudies-arrayexpress
TranscriptomicsDesign and testing of genome-proxy microarrays to profile marine microbial communities
Microarrays are useful tools for detecting and quantifying specific functional and phylogenetic genes in natural microbial communities. In order to track uncultivated microbial genotypes and their close relatives in an environmental context, we designed and implemented a “genome proxy” microarra...
ORGANISM(S): marine metagenome 
2010-05-25 | E-GEOD-9384 | biostudies-arrayexpress
TranscriptomicsTHE GOOD, THE BAD, AND THE TOXIC: DECIPHERING HORMESIS IN DAPHNIA MAGNA EXPOSED TO AN ENERGETIC COMPOUND
Hormesis is a dose response phenomenon characterized by a stimulation of an organismal response at low doses of a chemical and inhibition of the response (toxicity) at a higher dose. In the present study, Daphnia magna were exposed to the energetic compound 2,4,6-trinitrotoluene (TNT) for 21 days, ...
ORGANISM(S): Daphnia magna 
2013-02-01 | E-GEOD-43960 | biostudies-arrayexpress
TranscriptomicsSub-adult RDX Exposure, Whole Body Tissue Investigation
We investigated ecotoxicological effects and toxicogenomic responses in fathead minnows (Pimephales promelas) exposed to an environmentally-relevant concentration (0.83 mg/L) of the munitions compound cyclotrimethylenetrinitramine (RDX) in one year and multi-generational assays. In the one year ass...
ORGANISM(S): Pimephales promelas 
2010-07-30 | E-GEOD-21102 | biostudies-arrayexpress
TranscriptomicsIntegrated approach to explore the mechanisms of aromatase inhibition and recovery on fathead minnow ovaries
Aromatase, a member of the cytochrome P450 superfamily, is a key enzyme in estrogen synthesis and is responsible for the aromatization of androgens into estrogens. Here, we used an integrated approach to better understand the effects of aromatase inhibition as well as the mechanisms involved in the ...
ORGANISM(S): Pimephales promelas 
2013-11-01 | E-GEOD-51961 | biostudies-arrayexpress
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