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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
UnknownEfficacy and safety of PM-AR-T versus edwards MC3 rings in tricuspid regurgitation: A non-inferiority, randomized controlled trial.
Not available
S-EPMC12700415 | biostudies-literature
GenomicsGenome-wide methylation and expression analysis of two breast cancer cell lines [Methyl-MAPS]
To improve our understanding of the relationships between methylation and expression we profiled mRNA expression and single-base resolution methylation levels for two breast cancer cell lines, MCF7 and T47D. Expression was profiled using RNA-seq. Methylation was assayed using Methyl-MAPS, which use...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-45336 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human unstimulated regulatory T cells (Tregs) and naïve CD4+ T cells
Human regulatory T cells (TR) cells have potential for the treatment of immune mediated diseases, such as graft versus host disease, but the anergic phenotype of these cells makes them difficult to expand in vitro. We have examined the requirements for growth and cytokine expression from highly pur...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22045 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of wildtype and mutant HDAC1-/-;HDAC2+/- in 2-3 week old TCRb/CD5 low Mouse T cells
Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their exploitation as drug targets, we have generated mi...
ORGANISM(S): Mus musculus 
2013-01-08 | E-MTAB-1432 | biostudies-arrayexpress
UnknownConventional versus rapid-deployment aortic valve replacement: a single-centre comparison between the Edwards Magna valve and its rapid-deployment successor.
Not available
S-EPMC4986793 | biostudies-literature
TranscriptomicsLung gamma delta T cells in tumor-free and mammary tumor-bearing mice
Gamma delta T cells were sorted from the lungs of 4 female FVB/n mice (labeled wild-type [WT] 1-4) and 4 female mammary tumour-bearing K14-Cre;Brca1F/F;Trp53F/F (KB1P) mice (labeled Tumour 1-4).The sorted cells were loaded onto the Chromium Single Cell 30 Chip Kit v2 (10xGenomics) to generate librar...
ORGANISM(S): Mus musculus 
2021-07-12 | E-MTAB-10677 | biostudies-arrayexpress
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-09-23 | MTBLS1474 | MetaboLights
UnknownTubuca alcocki, a new pseudocryptic species of fiddler crab from the Indian Ocean, sister to the southeastern African T. urvillei (H. Milne Edwards, 1852) (Crustacea, Decapoda, Brachyura, Ocypodidae).
Not available
S-EPMC5904522 | biostudies-literature
TranscriptomicsGene-expression profile of the response to E. coli (k2bh2) infection in the bovine udder
Mastitis in dairy cows is one of the most costly and prevalent diseases affecting dairy cows world wide. Insight in the molecular regulation of the host immune response to an E. coli infection, could help to develop new strategies to prevent cattle from E. coli infection. Here we performed a gene-ex...
ORGANISM(S): Bos taurus 
2011-03-01 | E-GEOD-24217 | biostudies-arrayexpress
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