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MetabolomicsMetabolomic responses of Solanum lycopersicum to Tuta absoluta infestation and TaCRVP effector expression
This study presents the metabolomic profiling of Solanum lycopersicum in response to feeding by the herbivorous insect Tuta absoluta and the overexpression of its salivary effector, TaCRVP. To elucidate how this effector manipulates host immunity at the metabolic level, we performed untargeted LC-MS...
2026-05-18 | MTBLS14509 | MetaboLights
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
TranscriptomicsComparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice
We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, eff...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-02-29 | MSV000079540 | MassIVE
TranscriptomicsExpression profiling of Col-0 and rps2 treated with Psm:AvrRpt2
Identification of differential gene expression during RPS2-mediated effector-triggered immunity in Arabidopsis Four-week-old leaves of Arabidopsis Col-0 wild type and rps2 mutant plant were infiltrated with Pseudomonas syringae pv. Maculicola carring effector AvrRpt2 at OD 0.01. Samples were collect...
ORGANISM(S): Arabidopsis thaliana 
2016-09-01 | E-GEOD-72742 | biostudies-arrayexpress
GenomicsGlobal DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function
In response to acute infection CD8 T cells differentiate into effector cells capable of clearing the antigen. While the transcriptional and functional changes have previously been studied little is known of the epigenetic modifications that accompany this differentiation process. To gain insights ...
ORGANISM(S): Mus musculus 
2013-08-18 | E-GEOD-44638 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of effector T cells induced by mTOR inhibition
To further develop our gene expression approach to treatment of autoimmunity, we have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed upon immunosuppressor treatment responsible for inhibition of T cell effector functions. Huma...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-29606 | biostudies-arrayexpress
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, effe...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-04 | PXD001065 | Pride
Murine Cd8+ Lc-ms/ms 
TranscriptomicsTranscription profiling of in vitro generated CD8+ central memory (CM) and effector/effector memory (E/EM) T cells.
Expression profiles of in vitro generated CD8+ central memory (CM) and effector/effector memory (E/EM) T cells on Affymetrix GeneChip Murine Genome U74 Version 2 Set MG-U74A, MG-U74B, and MG-U74C. T cells were generated from female P14 T cell receptor transgenic mice on the C57Bl/6 genetic backgroun...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-561 | biostudies-arrayexpress
GenomicsSaccharomyces cerevisiae transcriptome response to overexpression of the Phytophthora sojae Avh110 effector
Saccharomyces cerevisiae transcriptome response to overexpression of the Phytophthora sojae Avh110 effector
PRJEB40324 | ENA
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