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MetabolomicsDecreased abundance of type III secretion systeminducing signals in Arabidopsis mkp1 enhances resistance against Pseudomonas syringae
Genes encoding the virulence-promoting type III secretion system (T3SS) in phytopathogenic bacteria are induced at the start of infection, indicating that recognition of signals from the host plant initiates this response. However, the precise nature of these signals and whether their concentrations...
2014-06-24 | MTBLS95 | MetaboLights
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsGlobal impact of Salmonella type III secretion effector SteA on host cells
Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems (T3SSs), encoded in pathogenicity islands 1 (SPI1) and 2 (SPI2), respectively. T...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-51043 | biostudies-arrayexpress
TranscriptomicsNetwork analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity
Plasma cells (PCs) as effectors of humoral immunity produce immunoglobulins to match pathogenic insult. However, emerging data suggests more diverse roles for PCs as regulators of immune and inflammatory responses via secretion of factors other than immunoglobulins. The extent to which such response...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-75007 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 pneumocyte cells infected with wild type and type III secretion system mutants of Pseudomonas aeruginosa
The bacterial type III secretion system (TTSS) is dedicated to directly effect host cell pathways by pathogens. In order to identify the key host responses of the various parts of the TTSS, we utilized expression profiling of a lung pneumocytes cell line, A549, exposed to various isogenic mutant str...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1469 | biostudies-arrayexpress
TranscriptomicsMacrophages recognize the Helicobacter pylori type IV secretion system in the absence of TLR signaling
Helicobacter pylori conquered the world by colonizing the human stomach. There are two major groups of strains, one with and one without a cag pathogenicity island (cagPAI), which result in different clinical outcomes with increased severity in cagPAI+ H. pylori infections such as higher inflammatio...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-56791 | biostudies-arrayexpress
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice
We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of Burkholderia pseudomallei Bsa Type III secretion system effectors using hyper-secreting mutants
Burkholderia pseudomallei is an intracellular pathogen and the causative agent of melioidosis, a severe disease of humans and animals. One of the virulence factors critical for early stages of infection is the Burkholderia secretion apparatus (Bsa) Type 3 Secretion System (T3SS), a molecular syringe...
ORGANISM(S): Burkholderia pseudomallei (strain K96243) 
2015-01-28 | PXD001656 | Pride
Effector T3ss Type iii secretion system Burkholderia pseudomallei Melioidosis Itraq 
TranscriptomicsGene expression profiles of effector T cells
This SuperSeries is composed of the following subset Series: GSE29606: Gene expression profiles of effector T cells induced by mTOR inhibition GSE29607: Comparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice Refer to individual Series
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29608 | biostudies-arrayexpress
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