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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target
Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology ...
2026-04-24 | MTBLS14357 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell ...

2026-03-13 | MTBLS13992 | MetaboLights
MetabolomicsIntegrated analysis of therapeutic efficacy and resistance mechanisms of lytic phages targeting ST218 K57 CR-hvKp
Clinical infection caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually increasing and spreading across the world, and phage therapy is a viable application as an alternative to antibiotics. However, additional clinical application is still restricted by the phag...
2025-09-18 | MTBLS12480 | MetaboLights
MetabolomicsDevelopment of a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var to target glutamine dependency in cancer

The mitochondrial glutamine transporter SLC1A5_var plays a central role in the metabolic reprogramming of cancer cells by facilitating glutamine import into mitochondria for energy production and redox homeostasis. Despite its critical function, the development of effective and selective inhibito...

2025-08-13 | MTBLS12852 | MetaboLights
TranscriptomicsEZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation [RNA-Seq]
Here we report the discovery of highly potent and selective EZH2 small molecule inhibitors, their validation by a cellular thermal shift assay, their application across a large lymphoma cell panel and their efficacy in GCBDLBCL xenograft models. RNA-seq of KARPAS-422 cell line RNA, in duplicate, tre...
ORGANISM(S): Homo sapiens 
2015-04-13 | E-GEOD-62056 | biostudies-arrayexpress
ModelsStephanou2019 - pH as a potential therapeutic target to improve temozolomide antitumor efficacy
Abstract: Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inc...
2019-09-30 | MODEL1909300003 | BioModels
TranscriptomicsTranscription profiling of mouse ears exposed to sulfur mustard alone, sulfur mustard preceded by drug treatment, or vehicle compounds to identify gene expression changes that correlate with compound efficacy
Sulfur mustard (SM) is a potent alkylating agent. We are developing medical countermeasures to reduce the injury caused by SM exposure. Screening in the mouse ear vesicant model has identified three effective compounds: dimercaprol (British anti-lewisite), indomethacin, and octyl homovanillamide (OH...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2950 | biostudies-arrayexpress
TranscriptomicsEfficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
Primary effusion lymphoma is an aggressive B-cell lymphoma most commonly diagnosed in HIV-positive patients and universally associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). Chemotherapy treatment of PEL yields only short-term remissions in the vast majority of patients yet efforts to ...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-22594 | biostudies-arrayexpress
TranscriptomicsTarget mRNAs induce tailing and trimming of Ago2-loaded miRNAs in neurons
We show that target mRNAs trigger the non-templated addition of nucleotides (mainly adenosines and uridines) and shortening of their cognate miRNAs in primary hippocampal neurons. The induced effect is observable both in total RNA and in Ago2-associated RNA, demonstrating that the process is initiat...
ORGANISM(S): Rattus norvegicus 
2015-03-02 | E-GEOD-57663 | biostudies-arrayexpress
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