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TranscriptomicsNanog Independent Reprogramming to iPSCs with Canonical Factors
It has been suggested that the transcription factor Nanog is essential for the establishment of pluripotency during the derivation of embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. However, successful reprogramming to pluripotency with a growing list of divergent transcription f...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-53212 | biostudies-arrayexpress
GenomicsDAC for Human Stem Sell Sequencing
Data Access Committee EGAC00001000642
EGAC00001000642 | EGA
GenomicsDNA methylation dynamics of the human pre-implantation embryo
We present genome-scale maps of DNA methylation in early human development and perform comparative analysis to mouse that confirm a conserved global erasure of the paternal genome. We find that while many global features of the early embryo are consistent between the two species, the target sequenc...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-51239 | biostudies-arrayexpress
TranscriptomicsGene expression of genetically related and unrelated human embryonic stem cell lines
Gene expression of sibling human ES cell lines are more similar to each other than unrelated cell lines. Undifferentiated human embryonic stem cells were used for analysis. We sought to determine whether genetic differences underly variations between different human ES cell lines. Sibling cell lines...
ORGANISM(S): Homo sapiens 
2009-03-19 | E-GEOD-15294 | biostudies-arrayexpress
TranscriptomicsPathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neural degeneration. Here, we have combined reprogramming...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-54409 | biostudies-arrayexpress
Genomicsena-DATASET-HU-17-07-2017-20:03:05:530-176 - samples
This dataset includes deep coverage (>60x) whole exomes of 15 human embryonic stem cell lines. Genomic DNA was purified and fragmented using the Illumina Nextera system for library preparation and sequenced using 150bp paired-end reads. Sequencing reads were aligned to the hg19 reference genome usin...
EGAD00001003446 | EGA
GenomicsBiological insights from the whole genome sequences of human embryonic stem cell lines
Human embryonic stem cells (hESCs) are a powerful tool for the study of human development and can form the basis of cellular disease models or therapies. However, the genetic make-up and stability of hESCs has not been systematically studied at a genome-wide level with single nucleotide resolution. ...
EGAS00001002400 | EGA
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