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Epigenetic reprogramming is commonly observed in cancer, and is hypothesized to involve multiple mechanisms, including DNA methylation and Polycomb repressive complexes (PRCs). Here we devise a new experimental and analytical strategy using customized high density tiling arrays to investigate coordi...
ORGANISM(S): Homo sapiens 
DNA methylation is an important epigenetic mechanism, affecting normal development and playing a key role in reprogramming epigenomes during stem cell derivation. Here we report on DNA methylation patterns in native monkey embryonic stem (ES) cells, fibroblasts and ES cells generated through somatic...
ORGANISM(S): Macaca mulatta 
Three Xuta varieties (JPNT1, JPNT2, and JPNT3) harvested in three consecutive years (2022, 2023, and 2024) were analysed. The harvested seeds were sun-dried for 2-3 days, de-hulled immediately, and the kernels dried further on plastic or fibre mats under direct sunlight until the moisture content wa...
ORGANISM(S): Jatropha Curcas (ncbitaxon:180498) 
Agonist-induced cardiac hypertrophy in TG1306/1R transgenic mice with cardiac angiotensin II overproduction leads to a gradual transition from a compensatory hypertrophic state to heart failure. To gain insight into the molecular mechanisms that play a role in maintaining cardiac integrity in the di...
ORGANISM(S): Mus musculus 
Histone acetylation is an important, reversible posttranslational protein modification and hallmark of epigenetic regulation. However, little is known about the dynamics of reversible hisotne acetylation, due to the lack of analytical methods that can capture site-specific acetylation and deacetylat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD027338 | Pride
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