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TranscriptomicsExamination of gene expression in human breast cancer cells exposed to the HDAC inhibitor SAHA
The identification of proteins that change in response to a drug perturbation can shed light on the molecular mechanisms of the drug and its potential use in therapies. Histone deacetylases (HDACs) are targets for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is an FDA approved HDAC inhibit...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-60124 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in response to ING2 knockdown by siRNA in human breast cancer cells
The Sin3/HDAC multi-protein complex consists of at least 17 subunits and is known to have roles in diverse biological and cellular processes including transcription, chromatin structure, and the cell cycle. ING2 is a non-catalytic component of this complex. To obtain a better mechanistic understandi...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-60123 | biostudies-arrayexpress
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