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GenomicsJanthinobacterium lividum strain:EIF2
Janthinobacterium lividum strain:EIF2 Genome sequencing
PRJNA610480 | ENA
TranscriptomicsThe eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER ...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-29929 | biostudies-arrayexpress
TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
TranscriptomicsSelective mRNA translation during eIF2 phosphorylation induces expression of IBTKalpha
Disruption of protein folding in the endoplasmic reticulum triggers the Unfolded Protein Response (UPR), a transcriptional and translational control network designed to restore protein homeostasis. Central to the UPR is PERK phosphorylation of the alpha subunit of eIF2 (eIF2~P), which represses glob...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-54581 | biostudies-arrayexpress
ProteomicsRecruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B
HDX-MS of R15B and it's interactions with trimeric eIF2 substrate. Here we integrated diverse approaches to elucidate how the PP1 non-catalytic subu-nit PPP1R15B (R15B) captures its full trimeric eIF2 substrate. We found that the substrate recruitment module of R15B is largely disordered with three...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047538 | Pride
Hdx-ms Hd-ms 
TranscriptomicsSelective control of metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
When eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. We examine how yeast growth and tRNA charging or aminoacylation is affected during amino acid depletion in the presence and absence of GCN2. tRNA charging is measured using ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-01 | E-GEOD-22452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver to assess the translational response following activation of GCN2 versus PERK - super series
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Gcn2 wild-type and knockout liver perfused with or without methionine
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Perk wild-type and knockout liver perfused without or with 2,5-di-tert-butylhydroquinone
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11684 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of either LFD and HFD-treated Alb::GC mice and AP20187-treated TTR::Fv2E-PERK mice
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2alpha (eIF2a)-specific phosphatase, GADD34, was used to selectively ...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11210 | biostudies-arrayexpress
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