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ProteomicsRNA helicase EIF4A1-mediated translation is essential for the GC response
EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5’ untranslated regions. However, very little is known of their roles in non-malignant cells. Using mouse models to d...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-09 | PXD046710 | Pride
Eif4a1 B cells Translation 
ProteomicseIF4A1 unwinding activity is RNA sequence-specifically deployed through eIF4A1-multimerisation to facilitate translation of mRNAs with local repressive RNA structure
Oncogenic translational programmes are an emerging hallmark of cancer and often driven by dysregulation of signaling pathways including KRAS and mTORC that converge on the eukaryotic translation initiation (eIF) 4F complex. Altered eIF4F activity promotes translation of oncogene mRNAs that typically...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD034343 | Pride
Proteomics Tmt Eif4a1 Pulse silac 
ProteomicsProteomic research on effect of EIF4A1 inhibition in MYC-amplified Group 3 medulloblastoma
As the most life-threatening subtype of pediatric medulloblastoma (MB), MYC-amplified Group 3 (G3) MB lacks effective and selective therapeutics. We tried to indirectly target MYC (oncogenic driver and cancer-dependent molecule) production via inhibiting translational machinery. Through multiple dat...
ORGANISM(S): Homo Sapiens 
2020-10-15 | PXD022014 |
GenomicseIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition
eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition
PRJNA763797 | ENA
GenomicsAuthentication of Hippuristanol-eIF4A1 Target Engagement Facilitates Identification of eIF4A1 Helicase Dependencies within 5’ Leader Regions
Authentication of Hippuristanol-eIF4A1 Target Engagement Facilitates Identification of eIF4A1 Helicase Dependencies within 5’ Leader Regions
PRJNA636959 | ENA
UnknowneIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
Not available
S-EPMC9976904 | biostudies-literature
GenomicsEIF4A1 is essential in B cells by promoting activation-induced translation
EIF4A1 is essential in B cells by promoting activation-induced translation
PRJNA994938 | ENA
GenomicsIdentification of eIF4A1-binding RNAs in human prostate cancer cell line DU145
Identification of eIF4A1-binding RNAs in human prostate cancer cell line DU145
PRJNA679235 | ENA
UnknownEpigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.
Not available
S-EPMC9215223 | biostudies-literature
GenomicsTranscriptional profiling of mouse small intestinal tissue with Eif4a1/4a2 mutation
Transcriptional profiling of mouse small intestinal tissue with Eif4a1/4a2 mutation
PRJNA1003091 | ENA
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