Eilebrecht Elke E

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Transcriptomics (2)
Proteomics (2)

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Danio rerio (2)
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EFO:0001352 (2)
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Nostoc sp. PCC 7120 = FACHB-418 (2)
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biostudies-arrayexpress (2)
pride (2)

Tissue

Liver (2)
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Technology Type

Mass Spectrometry (2)
Shotgun proteomics (2)

Instrument Platform

Illumina NovaSeq 6000 (1)
Illumina HiSeq 4000 (1)

Publication Date

2019 (2)
2023 (1)
2022 (1)

Study type

RNA-seq of coding RNA (2)

Release Date

2023 (1)
2022 (1)

Lab affiliation

Dr. Elke Eilebrecht Ecotoxicology Fraunhofer Institute for Molecular Biology and Applied Ecology IME Auf dem Aberg 1 │ 57392 Schmallenberg Tel. +49 2972 302-144 │ Fax 02972 302-319 elke.eilebrecht@ime.fraunhofer.de │ www.ime.fraunhofer.de/en.html (1)
Ecotoxicology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Schmallenberg, Germany. (1)

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A quantitative proteomic based approach for identifying and characterizing APAP-induced liver perturbation in zebrafish (Danio rerio)

The relative quantification of sex-specific proteomic responses led to the detection of potential biomarkers for hepatotoxicity and as well as the identification of the underlying molecular perturbation needed to unravel the impact of APAP-induced liver injury on physiological system.

ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio)

2019-11-18 | PXD013357 | Pride

Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression

Within the regulatory framework on the approval of new substances, the assessment of immunotoxic modes of action (MoA) is currently not covered. This is not least due to the lack of standardized methods and reliable validated biomarkers for immunotoxic effects. The experimental set up was designed t...

ORGANISM(S): Danio rerio

2023-12-01 | E-MTAB-13263 | biostudies-arrayexpress

A quantitative proteomics-approach to detect impaired estrogen synthesis in zebrafish (Danio rerio)

Identification and relative quantification of proteins associated with substance specific alterations and sex-specific physiological responses following aromatase inhibition.

ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio)

2019-04-30 | PXD011022 | Pride

Endocrine disruptors Adverse outcome pathways (aop) Omics Toxicity pathways Zebrafish

Transcriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos

The aim of this experiment was to develop an approach for the assessment of immunotoxicity in zebrafish embryos (Danio rerio) using transcriptomic profiling. Clobetasol propionate, a highly potent synthetic corticosteroid, which is known to have immunosuppressive effects on vertebrates including zeb...