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MetabolomicsMechanism of Hepatotoxicity Induced by Ethanol Extract of Emilia sonchifolia (L.) DC Revealed by Proteomics and Metabolomics

Objective: Hepatotoxicity has been reported for Emilia sonchifolia (L.) DC (Emilia sonchifolia). The plant material is typically prepared using two extraction methods for practical application: water extraction and ethanol extraction. However, our previous research only investigated its wate...

2025-10-30 | MTBLS13237 | MetaboLights
MetabolomicsHepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3,5,6-trichloro-2-pyridinol, in orally exposed mice
3,5,6-Trichloro-2-pyridinol (TCP) is a primary degradation product of chlorpyrifos and chlorpyrifos-methyl. TCP has longer half-life in soil and greater solubility in water than its parent compound, and cause wide contamination in environments. However, studies about the toxic effects of TCP are lim...
2017-05-05 | MTBLS275 | MetaboLights
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Given that Aflatoxin B1 exposure drives 5% to 28% of global hepatocellular carcinoma cases, the critical paucity of effective interventions for Aflatoxin B1-induced liver injury represents an urgent need. Here, we discover that a cereal-derived polyph...

2026-08-13 | MTBLS13667 | MetaboLights
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
ProteomicsLicorice Ameliorates Cisplatin-Induced Hepatotoxicity through Anti-apoptosis, Anti-oxidative Stress, Anti-inflammation, and Acceleration of Metabolism
Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a traditional herbal medicine, has been commonly used as a detoxifier for poisons and drugs, and may be an effective dr...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-27 | PXD021688 | Pride
Proteomics Hepatotoxicity Detoxification Cisplatin Licorice 
GenomicsSuppression of APAP-induced hepatotoxicity using Slit2
Suppression of APAP-induced hepatotoxicity using Slit2
PRJNA1236219 | ENA
ProteomicsProteomic investigations of transcription factors critical in geniposide-mediated suppression of alcoholic steatosis and in overdose induced hepatotoxicity on liver
Geniposide mediated therapeutic effects and overdose-induced hepatotoxicity
ORGANISM(S): Rattus Rattus 
PXD014996 |
Proteomicsproteomic data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity
proteomic data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-27 | PXD016625 | Pride
Proteomics lc-ms 
ProteomicsProteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium Wilfordii multiglycoside in mice
Tripterygium wilfordii multiglycoside (GTW), extracted and purified from the peeled roots of Tripterygium wilfordii Hook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has been reported to cause severe liver injury. At prese...
ORGANISM(S): Mus Musculus 
2022-11-10 | PXD038084 |
UnknownUnited States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.
Not available
S-EPMC7044683 | biostudies-literature
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