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MetabolomicsEpimedium-Derived Extracellular Vesicles Alleviate Cisplatin-induced Acute Kidney Injury: Integrated Multi-Omics Analysis and Molecular Simulations Reveal Flavonoid Interactions with PPARα
This study explores the protective effects and potential underlying mechanisms of Epimedium-derived extracellular vesicles (EpEVs) against cisplatin-induced acute kidney injury (CIAKI) in mice. EpEVs were isolated and purified via differential centrifugation combined with sucrose and iodixanol gradi...
2026-09-02 | MTBLS15534 | MetaboLights
TranscriptomicsExpression data identifying hypermethylated genes associated with acquired cisplatin resistance
Treatment-related DNA hypermethylation may play a role in creating drug resistant phenotypes by inactivating genes that are required for cytotoxicity, but there have been no genome-wide studies to systematically investigate methylation of individual genes following exposure to chemotherapy. We used ...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19397 | biostudies-arrayexpress
TranscriptomicsReal-time Monitoring of Cisplatin Toxicity on Cancer Cells
Treatment of MCF7 breast cancer cells by cisplatin leads to a very specific metabolic response and an onset of cell death about 10-11 h after beginning of treatment. For more detailed understanding of the molecular processes underlying the specific metabolic response, mRNA was isolated from MCF7 cel...
ORGANISM(S): Homo sapiens 
2011-04-04 | E-GEOD-28274 | biostudies-arrayexpress
TranscriptomicsComparison of H460 derived CSCs and cisplatin-resistant cells
Transcription profile of cancer stem cells isolated from human non-small cells lung cancer (NSCLC) H460 cells. The profile of H460 cells that were made resistant to cisplatin after a single treatment with the drug was also determined. Both profiles were finally compared. Each microarray contained on...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54981 | biostudies-arrayexpress
MetabolomicsThe metabolomic resetting effect of DMXAA in cisplatin-induced injured mouse kidney
Not available
ORGANISM(S): Mus musculus 
ST002390 | MetabolomicsWorkbench
TranscriptomicsTranscript analyses of cisplatin and Sky1 effects in Saccharomyces cerevisiae
Sky1 is a Saccharomyces cerevisiae rich serine-arginine (SR) protein-specific kinase and its enzymatic activity is essential in the cytotoxicity caused by cisplatin, although the molecular mechanisms supporting this function are not understood. We present a transcriptome analysis discriminating betw...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-41094 | biostudies-arrayexpress
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
TranscriptomicsApoptosis induced by Piroxicam/Cisplatin combined treatment is triggered by p21 in mesothelioma
Here we report that piroxicam/cisplatin combined treatment exerts an apoptotic effect on mesothelioma cells. Genome-wide transcriptome analyses lead us to identify p21 as the possible apoptosis mediator acting as downstream target of the piroxicam/cisplatin treatment. To analyze the potential therap...
ORGANISM(S): Homo sapiens 
2011-11-20 | E-GEOD-22445 | biostudies-arrayexpress
TranscriptomicsDichloroacetate (DCA) prevents cisplatin-induced nephrotoxicity without compromising its anti-cancer properties.
The aim of this study was to compare the transcriptional changes that occur in the kidneys of mice administered cisplatin or DCA, or both, by RNA-seq. generation of RNA-seq datasets from mice subjected to 4 different treatments. 3 biological replicates per treatment. Saline treatment is control.
ORGANISM(S): Mus musculus 
2016-03-09 | E-GEOD-69652 | biostudies-arrayexpress
MetabolomicsReprogrammed Lipid Metabolism in Bladder Cancer with Cisplatin Resistance
Not available
ORGANISM(S): Homo sapiens 
ST001120 | MetabolomicsWorkbench
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