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TranscriptomicsDual inactivation of Akt and ERK by small molecule TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction and potent anti-tumor effects
TIC10-induced transcriptional changes at 48hrs in HCT116 p53-null cells (10uM). Six samples of HCT116 p53-null cells with TIC10 (10uM) or DMSO treatment. Three replicates each.
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-34194 | biostudies-arrayexpress
UnknownONC201 and imipridones: Anti-cancer compounds with clinical efficacy.
Not available
S-EPMC7588802 | biostudies-literature
TranscriptomicsAnti-cancer agent ONC201 activates early ATF4/DR5 upregulation, and cell death associated with XIAP inhibition
Two experiments were performed with ONC201/TIC10 in human colon cancer cell lines. The first experiment is TIC10-induced transcriptional changes at 48hrs in HCT116 p53-null cells (10uM). The second experiment is RKO cells, with and without acquired resistance to ONC201, treated with with ONC201 (10u...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-72865 | biostudies-arrayexpress
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