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ProteomicsTAF8 MUTATION CAUSES INTELLECUAL DISABILITY, TFIID DISASSEMBLY WITH NO EFFECT ON RNA POLYMERASE II TRANSCRIPTION
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID nucleates RNA Polymerase II (Pol II) preinitiation complex formation on gene promoters and thus, is crucial for Pol II transcription. Germline k...
ORGANISM(S): Homo sapiens (Human) 
2018-04-16 | PXD008084 | Pride
Tata binding protein (tbp) Chromatin immunoprecipitation (chip) Frame shift Intellectual disability Rna polymerase ii (pol ii) Patient Tfiid Tbp-associated factor (taf) Splice site mutation 
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