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TranscriptomicsGenome-wide regulation by TFIID and SAGA
TFIID and SAGA share a common set of TAFs, regulate chromatin, and deliver TBP to promoters. Here we examine their relationship within the context of the Saccharomyces cerevisiae genome-wide regulatory network. We find that while TFIID and SAGA make overlapping contributions to the expression of al...
ORGANISM(S): Saccharomyces cerevisiae 
2004-02-26 | E-GEOD-885 | biostudies-arrayexpress
TranscriptomicsA central role for TFIID in the pluripotent transcription circuitry [PP003]
Pluripotent stem cells can be isolated from early embryos or induced by cell fusion, somatic nuclear transfer, or expression of a selected set of transcription factors. Embryonic stem (ES) cells are characterized by an open chromatin configuration and high transcription levels achieved via autoregul...
ORGANISM(S): Mus musculus 
2013-03-21 | E-GEOD-33645 | biostudies-arrayexpress
TranscriptomicsA central role for TFIID in the pluripotent transcription circuitry [PP002]
Pluripotent stem cells can be isolated from early embryos or induced by cell fusion, somatic nuclear transfer, or expression of a selected set of transcription factors. Embryonic stem (ES) cells are characterized by an open chromatin configuration and high transcription levels achieved via autoregul...
ORGANISM(S): Mus musculus 
2013-03-21 | E-GEOD-33644 | biostudies-arrayexpress
ProteomicsCrosslinking Mapping of yeast Komagataella phaffii TFIID complex
Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. We used CXMS to study the organization and st...
ORGANISM(S): Komagataella phaffii 
2018-10-08 | PXD011092 | Pride
K. phaffii tfiid cxms bs3 
TranscriptomicsHolo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.
TFIID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID is more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system we depleted TAF1 from Drosophila cells and d...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-45873 | biostudies-arrayexpress
ProteomicsTAF8 regions important for TFIID lobe B assembly are required for embryonic stem cell survival
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA polymerase II (Pol II) preinitiation complex formation on all protein coding gene promoters and thus, be crucial for ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-02 | PXD026575 | Pride
Embryonic stem cell (esc) Taf8 Tfiid Cxms 
ProteomicsRNA polymerase II transcription with partially assembled TFIID complexes
RNA polymerase II (Pol II) transcription initiation starts with the assembly of the preinitiation complex (PIC) on core promoters. The PIC is composed of six general transcription factors (GTFs). The recognition of the core promoter sequences by the TFIID GTF complex is the first step of the PIC ass...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD046459 | Pride
Transcription Rna polymerase Tfiid 
ProteomicsChaperonin CCT Checkpoint Function in Basal Transcription Factor TFIID Assembly
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit composition exist and several TFIID subunits are shared with other complexes, conveying intricate cellular decision making to control subunit allocation and functional assembly of this essential transc...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD011211 | Pride
Proteomics Crystal structure Tfiid Chaperonin cct 
ProteomicsChaperonin CCT Checkpoint Function in Basal Transcription Factor TFIID Assembly
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit composition exist and several TFIID subunits are shared with other complexes, conveying intricate cellular decision making to control subunit allocation and functional assembly of this essential transc...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011293 | Pride
Tric/cct chaperonin Mutagenesis Tfiid Crystal structure 
ProteomicsCytoplasmic complex comprising TAF2, TAF8, TAF10 provides evidence for nuclear holo-TFIID assembly from preformed submodules
General transcription factor TFIID is a cornerstone of RNA polymerase II transcription initiation in eukaryotic nuclei. Human TFIID is a megadalton-sized multiprotein complex composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). The cellular mechanism of TFIID assembly is ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-15 | PXD001427 | Pride
Assembly Tfiid Tafstructure Mudpit analysis 
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