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GenomicsStranded RNA-seq profiling of cerebral cortices from Taf8-deleted and Taf8-intact mouse embryos
Stranded RNA-seq profiling of cerebral cortices from Taf8-deleted and Taf8-intact mouse embryos
PRJNA815651 | ENA
GenomicsUnstranded RNA-seq profiling of cerebral cortices from Taf8-deleted and Taf8-intact mouse embryos
Unstranded RNA-seq profiling of cerebral cortices from Taf8-deleted and Taf8-intact mouse embryos
PRJNA815650 | ENA
GenomicsRNA-seq expression profiling of cerebral cortices from Taf8 deleted and Taf8 intact mouse embryos
RNA-seq expression profiling of cerebral cortices from Taf8 deleted and Taf8 intact mouse embryos
PRJNA815647 | ENA
ProteomicsTAF8 MUTATION CAUSES INTELLECUAL DISABILITY, TFIID DISASSEMBLY WITH NO EFFECT ON RNA POLYMERASE II TRANSCRIPTION
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID nucleates RNA Polymerase II (Pol II) preinitiation complex formation on gene promoters and thus, is crucial for Pol II transcription. Germline k...
ORGANISM(S): Homo sapiens (Human) 
2018-04-16 | PXD008084 | Pride
Tata binding protein (tbp) Chromatin immunoprecipitation (chip) Frame shift Intellectual disability Rna polymerase ii (pol ii) Patient Tfiid Tbp-associated factor (taf) Splice site mutation 
ProteomicsTAF8 regions important for TFIID lobe B assembly are required for embryonic stem cell survival
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA polymerase II (Pol II) preinitiation complex formation on all protein coding gene promoters and thus, be crucial for ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-02 | PXD026575 | Pride
Embryonic stem cell (esc) Taf8 Tfiid Cxms 
TranscriptomicsStranded RNA-seq profiling of cerebral cortices from Taf8-deleted and Taf8-intact mouse embryos
Taf8 was deleted in the mouse central nervous system using our Taf8 conditional allele. To determine transcriptional changes due to Ta8 deletion in the developing CNS, stranded RNA sequencing was performed on cortices from Taf8 deleted embryos (E14.5 Taf8lox/–NesCreT/+p53–/–) and control embryos (E1...
ORGANISM(S): Mus musculus 
2022-03-12 | GSE198502 | GEO
TranscriptomicsUnstranded RNA-seq profiling of cerebral cortices from Taf8-deleted and Taf8-intact mouse embryos
Taf8 was deleted in the mouse central nervous system using our Taf8 conditional allele. To determine transcriptional changes due to Ta8 deletion in the developing CNS, unstranded RNA sequencing was performed on cortices from Taf8 deleted embryos (E14.5 Taf8lox/–NesCreT/+p53–/–) and control embryos (...
ORGANISM(S): Mus musculus 
2022-03-12 | GSE198503 | GEO
TranscriptomicsRNA-seq expression profiling of cerebral cortices from Taf8 deleted and Taf8 intact mouse embryos
Mutations in genes encoding general transcription factors cause neurological disorders. Despite clinical prominence, the consequences of defects in the basal transcription machinery during brain development are unclear. We found that loss of the TATA-box binding protein associated factor TAF8, a com...
ORGANISM(S): Mus musculus 
2022-03-12 | GSE198505 | GEO
ProteomicsImportance of TAF8 regions for TFIID lobe B assembly, or for TAF2 interactions, are required for embryonic stem cell survival
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA polymerase II (Pol II) preinitiation complex formation on all protein coding gene promoters and thus, be crucial for ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028352 | Pride
Tata binding protein (tbp) Tbp-associated factors (tafs) Viability Knock out Function Taf8 Structure Tfiid Crispr/cas9 Baculovirus over expression Embryonic stem cells (escs) Taf complexes 
UnknownHomozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.
Not available
S-EPMC5985725 | biostudies-literature
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