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ProteomicsProteomic and cellular responses against mutagenesis
Endogenous stress represents a major source of genome instability, but is in essence difficult to apprehend. Incorporation of labeled radionuclides into DNA constitutes a tractable model to analyze cellular responses to endogenous attacks. Here we show that incorporation of [3H]thymidine into CHO ha...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2016-07-15 | PXD003542 | Pride
Endogenous stress Tritium Oxidative stress Proteomic Mutagenesis Low doses 
TranscriptomicsInterrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera.
Background Neisseria meningitidis is an important human commensal and pathogen that causes several thousand deaths each year, mostly in young children. How the pathogen replicates and causes disease in the host is largely unknown, particularly the role of metabolism in colonization and disease. Com...
ORGANISM(S): Neisseria meningitidis 
2012-01-23 | E-BUGS-129 | biostudies-arrayexpress
MetabolomicsA multi-omics study on the metabolic reprogramming of a chlorophyll-deficient, high-protein Auxenochlorella pyrenoidosa mutant (CX41) generated by atmospheric and room temperature plasma (ARTP) mutagenesis.

This project aims to elucidate the molecular mechanism underlying the stable golden-yellow phenotype and enhanced protein accumulation in an Auxenochlorella pyrenoidosa mutant (CX41) generated by ARTP mutagenesis. Through comparative analysis between the wild-type (FACHB-9) and mutant s...

2025-12-26 | MTBLS13574 | MetaboLights
TranscriptomicsRetroviral insertional mutagenesis screen in a C/EBPalpha proliferative genetic background
The CCAAT enhancer binding protein alpha (C/EBPalpha) transcription factor plays a key role in the regulation of growth and differentiation of the granulocytic lineage in the hematopoietic system and CEBPA (encoding C/EBPalpha) is often mutated or deregulated in AML patients. Consistently, mice lack...
ORGANISM(S): Mus musculus 
2008-05-31 | E-GEOD-8032 | biostudies-arrayexpress
GenomicsClonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-46210 | biostudies-arrayexpress
UnknownPilot study of large-scale production of mutant pigs by ENU mutagenesis.
Not available
S-EPMC5505698 | biostudies-literature
GenomicsPolk mutagenesis
Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polk and DNA repair
PRJEB82830 | ENA
TranscriptomicsTranscription profiling of rice reveals plant mutagenesis may induce more transcriptomic changes than transgene insertion
Controversy regarding genetically modified (GM) plants and their potential impact on human health contrasts with the tacit acceptance; of other plants that were also modified, but not considered as GM products (e.g., varieties raised through conventional breeding such as mutagenesis). What is beyond...
ORGANISM(S): Oryza sativa 
2008-11-04 | E-GEOD-12069 | biostudies-arrayexpress
UnknownMultiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
Not available
S-EPMC28386 | biostudies-literature
GenomicsBackground mutagenesis during prolonged exposure
Background mutagenesis during prolonged exposure
PRJEB34943 | ENA
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