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ProteomicsPresence of ceramidase activity in electronegative LDL
Electronegative LDL (LDL(-)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them, LDL(-) has increased content of bioactive lipid mediators, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), w...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD036168 | Pride
Electronegative ldl  ceramide  sphingosine  ceramidase  sphingomyelinase 
TranscriptomicsExpression data from ARPE-19 cells treated with LDL or ox-LDL
LDL or Ox-LDL 200ug/ml, which showed no loss of viability after a 48 hour exposure, induced a physiological and pathological transcriptional response, respectively. LDL induced a downregulation of genes associated with cholesterol biosynthesis while ox-LDL induced transcriptional alterations in gene...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5741 | biostudies-arrayexpress
UnknownPresence of Ceramidase Activity in Electronegative LDL.
Not available
S-EPMC9820682 | biostudies-literature
TranscriptomicsTranscription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL
Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-360 | biostudies-arrayexpress
UnknownElectronegative LDL from Rabbits Fed with Atherogenic Diet Is Highly Proinflammatory.
Not available
S-EPMC6724430 | biostudies-literature
UnknownElectronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease.
Not available
S-EPMC5240592 | biostudies-literature
UnknownHuman electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
Not available
S-EPMC6052487 | biostudies-literature
UnknownThe Role of Distinctive Sphingolipids in the Inflammatory and Apoptotic Effects of Electronegative LDL on Monocytes.
Not available
S-EPMC6722802 | biostudies-literature
UnknownElectronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis.
Not available
S-EPMC9952764 | biostudies-literature
TranscriptomicsLectin-type oxidized LDL receptor 1 defines population of polymorphonuclear myeloid-derived suppressor cells in cancer patients
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are important regulators of immune responses and promoters of tumor progression in cancer1,2. The heterogeneity of these cells as well as their distinction from neutrophils hampers the progress in understanding of the biology and clinical...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-79404 | biostudies-arrayexpress
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