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UnknownRole of low-density lipoprotein receptor rs5925 (1959C>T) gene polymorphism in pathogenesis of dyslipidemia among Egyptian lupus nephritis patients.

Objectives

This study aims to investigate the prevalence of low-density lipoprotein receptor (LDL-R) rs5925 genetic variants and to evaluate their relationship with plasma lipid and kidney functions in lupus nephritis patients.

Patients and methods

Between September 2020 and June 2021...
S-EPMC9985366 | biostudies-literature
UnknownMetabolites profiling of Mimusops caffra leaf via multiplex GC-MS and UPLC-MS/MS approaches in relation to its antioxidant and anti-inflammatory activities.
Mimusops caffra is a small to medium-sized fruit-producing tree belonging to the Sapotaceae family with potential commercial, medicinal, and nutritional value. The main goal of the current study is to profile the phytochemical composition of M. caffra leaf targeting both volatile and non-volatile me...
S-EPMC12041594 | biostudies-literature
UnknownPrognostic value of lipid parameters among patients with heart failure: A systematic review and meta-analysis.

Aims

We sought to evaluate the prognostic value of different lipid parameters in patients with heart failure (HF).

Methods and results

Electronic databases including MEDLINE, Embase, CENTRAL, and Web of Science were searched to identify studies that reported the association of any of ...
S-EPMC12287811 | biostudies-literature
UnknownSafety and efficacy of triple combination therapy in hypertension and dyslipidemia: a systematic review and meta-analysis of randomized controlled trials.

Background

Hypertension (HTN) and dyslipidemia are major risk factors for cardiovascular diseases. Recently, researchers have investigated the potential benefits of combining multiple medications in one bill to improve their metabolic and cardiovascular efficacy.

Objectives

We investi...
S-EPMC12909691 | biostudies-literature
UnknownIntravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials.

Background

Randomized clinical trials (RCTs) evaluating the role of intravenous (IV) iron administration in patients with heart failure (HF) and iron deficiency (ID) have yielded inconsistent results.

Methods

Electronic search of MEDLINE, EMBASE and OVID databases was performed until ...
S-EPMC10293724 | biostudies-literature
UnknownCytotoxic Potential of Novel Quinoline Derivative: 11-(1,4-Bisaminopropylpiperazinyl)5-methyl-5H-indolo[2,3-b]quinoline against Different Cancer Cell Lines via Activation and Deactivation of the Expression of Some Proteins.
The current study evaluated the cytotoxic activity of 11-(1,4-bisaminopropylpiperazinyl)5-methyl-5H-indolo[2,3-b]quinoline (BAPPN), a novel derivative of 5-methyl-5H-indolo[2,3-b]quinoline, against hepatocellular carcinoma (HepG2), colon carcinoma (HCT-116), breast (MCF-7), and lung (A549) cancer ce...
S-EPMC10532317 | biostudies-literature
UnknownRadioprotective potential of whey protein against gamma irradiation-induced lingual damage.
Introduction: Ionizing radiation (IR) is effectively used in the treatment of oral malignancies; however, it might also significantly harm the surrounding tissues. Whey protein isolate (WP) is a protein derived from milk that exhibits a wide range of bioactivities. Therefore, the present rese...
S-EPMC10753789 | biostudies-literature
UnknownHospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials.
Coronavirus disease 2019 (COVID-19) has a wide-ranging spectrum of clinical symptoms, from asymptomatic/mild to severe. Recent research indicates that, among several factors, a low vitamin D level is a modifiable risk factor for COVID-19 patients. This study aims to evaluate the effect of vitamin D ...
S-EPMC9743115 | biostudies-literature
UnknownAssessing SARS-CoV-2 vaccine effectiveness in health workers: a cohort study conducted during the pandemic decline phase in five hospitals, affiliated to Al-Azhar University- Egypt.

Objective

A cohort study was conducted with the support of the WHO, where a standardized WHO protocol was followed to assess vaccine effectiveness (VE) against symptomatic RT‒PCR confirmed SARS‒CoV-2 infection among hospital health workers (HWs) eligible for vaccination at Al-Azhar Universit...
S-EPMC12465424 | biostudies-literature
UnknownVariation in global trauma care: a survey of 187 hospitals across 51 countries.

Background

Trauma is a heterogeneous disease entity, with high rates of mortality and morbidity observed globally. While the health systems in which trauma patients are cared for worldwide have been previously assessed to varying degrees, many of the system processes that shape trauma patien...
S-EPMC12598983 | biostudies-literature
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