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TranscriptomicsRibo_seq (aka ribosome profiling) analysis of control and Myc-induced U2OS cells
We used Ribo-seq to examine the effect of Myc activation on protein translation in U2OS cells and correalted these changes with alterations in RNA level measured by RNA-seq on tye same conditions. We also examined these effects in the presence of Torin-1, an inhibitor of mTOR We measure ribosome occ...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66927 | biostudies-arrayexpress
TranscriptomicsWide-scale analysis of alternative polyadenylation (APA) associated with proliferation and transformation using 3'-Seq
We mapped and quantified poly(A) sites in BJ and MCF10A cells under proliferative, arrested and transformed states Two human cell lines (BJ and MCF10A) examined under proliferative, arrested and transformed states
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-33592 | biostudies-arrayexpress
TranscriptomicsGRO-seq analysis of control and Myc-induced U2OS cells
We used GRO-seq to examine the effect of Myc activation on RNA transcription in U2OS cells. We measure in duplicates gene transcription rates in U2OS cells containing an inducible Myc expression vector that were induced or mock-treated in duplicates for 5 hours.
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66928 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of control and Myc-induced U2OS cells
We used RNA-seq to examine the effect of Myc activation on U2OS cells transcriptome. We also examined these effects in the presence of Torin-1, an inhibitor of mTOR We measure gene expression profiles in U2OS cells containing an inducible Myc expression vector that were induced or mock-treated in du...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66789 | biostudies-arrayexpress
TranscriptomicsTranscriptome-profiling (RNA-seq) and Ribosome-profiling (Ribo-seq) of BJ cells treated with Nutlin-3a, an MDM2 inhibitor, which induces p53.
We applied in parallel RNA-Seq and Ribosome-profiling analyses to immortalized human primary BJ fibroblast cells in which p53 was induced by Nutlin-3a RNA-seq, using Illumina HiSeq 2000, was applied to BJ cells treated with Nutlin-3a, at 5 timepoints: 0, 2, 4, 6, 19 hrs Ribosome profiling was applie...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-45785 | biostudies-arrayexpress
no omics definedTranscription profiling of wild type and Atm-/- mouse lymph nodes treated with ionizing radiation
The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a maste...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2118 | biostudies-arrayexpress
GenomicsBRD7 is a candidate tumour suppressor gene required for p53 function
Oncogene-induced senescence (OIS) is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations while others show a dysfunctional p53 pathway, frequently by unknown mechanisms. We identified BRD7, a bromodomain-containing protein whos...
ORGANISM(S): Homo sapiens 
2010-03-14 | E-GEOD-20076 | biostudies-arrayexpress
TranscriptomicsmiRNA profile of WI-38 cells and their progressively transformed derivatives
microRNA array of 4 cell lines: WI-38 primary fibroblasts (â??Controlâ??), slow growers (early passage after immortalization, Slow), fast growers (extensive passaging after immortalization) and fast growers transformed by constitutively activated mutant H-RasV12 (â??Rasâ??) WI-38 cells were grown in...
ORGANISM(S): Homo sapiens 
2016-01-29 | E-GEOD-77338 | biostudies-arrayexpress
UnknownSystematic identification of functional SNPs interrupting 3'UTR polyadenylation signals.
Not available
S-EPMC7451987 | biostudies-literature
UnknownCell-type-specific analysis of alternative polyadenylation using single-cell transcriptomics data.
Not available
S-EPMC6821429 | biostudies-literature
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