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TranscriptomicsWide-scale analysis of alternative polyadenylation (APA) associated with proliferation and transformation using 3'-Seq
We mapped and quantified poly(A) sites in BJ and MCF10A cells under proliferative, arrested and transformed states Two human cell lines (BJ and MCF10A) examined under proliferative, arrested and transformed states
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-33592 | biostudies-arrayexpress
TranscriptomicsTranscriptome-profiling (RNA-seq) and Ribosome-profiling (Ribo-seq) of BJ cells treated with Nutlin-3a, an MDM2 inhibitor, which induces p53.
We applied in parallel RNA-Seq and Ribosome-profiling analyses to immortalized human primary BJ fibroblast cells in which p53 was induced by Nutlin-3a RNA-seq, using Illumina HiSeq 2000, was applied to BJ cells treated with Nutlin-3a, at 5 timepoints: 0, 2, 4, 6, 19 hrs Ribosome profiling was applie...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-45785 | biostudies-arrayexpress
TranscriptomicsTranscriptome-profiling (RNA-seq) and Ribosome-profiling (Ribo-seq) in proliferation, quiescence, senescence and transformed states.
We applied in parallel RNA-Seq and Ribosome-profiling analyses to immortalized human primary BJ fibroblast cells under the following conditions: normal proliferation, quiescence (induced by serum depletion), senescence (induced by activation of the oncogenic RASG12V gene, and examined at early (5 da...
ORGANISM(S): Homo sapiens 
2013-03-24 | E-GEOD-42509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts synchronized and treated with 1.5 Gy irraditation to identify primary transcriptional regulation of cell-cycle-regulated genes upon DNA damage
The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the express...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7075 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal melanocytes and melamoma cell lines reveal defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7469 | biostudies-arrayexpress
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