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TranscriptomicsExpression data from kidneys of rats with and without cisplatin treatment
We investigated an acute kidney injury (AKI) model in rats induced by cisplatin (Cp) administration. The cisplatin is widely used since its biochemical and histopathological characteristics are representative of drug-induced AKI in humans. Male Wistar rats were dosed once ip with 0, 1 and 3 mg/kg ...
ORGANISM(S): Rattus norvegicus 
2016-08-23 | E-GEOD-85957 | biostudies-arrayexpress
TranscriptomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53082 | biostudies-arrayexpress
TranscriptomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (miRNA)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53083 | biostudies-arrayexpress
ProteomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (protein)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53084 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver response to genotoxic carcinogens at doses known to induce liver tumors in the 2-year rat bioassay - short term in vivo study
When applied in toxicological studies, the recently developed gene expression profiling techniques using microarrays, which brought forth the new field of toxicogenomics, facilitate the interpretation of a toxic compound?s mechanism of action. In this study, we investigated whether genotoxic carcino...
ORGANISM(S): Rattus norvegicus 
2005-05-15 | E-TOXM-16 | biostudies-arrayexpress
TranscriptomicsExpression data from kidneys of rats with and without glomerulonephritis
We investigated a glomerulonephritis (GN) model in rats induced by nephrotoxic serum (NTS) which contains antibodies against the glomerular basement membrane (GBM). The anti-GBM GN model in rats is widely used since its biochemical and histopathological characteristics are similar to crescentic neph...
ORGANISM(S): Rattus norvegicus 
2015-07-06 | E-GEOD-64265 | biostudies-arrayexpress
TranscriptomicsComparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver
At present, substantial efforts are focused on the development of in vitro assays coupled with M-bM-^@M-^]omicsM-bM-^@M-^] technologies for the identification of carcinogenic substances as an alternative to the classical 2-year rodent carcinogenicity bioassay. A prerequisite for the eventual regulat...
ORGANISM(S): Rattus norvegicus 
2012-04-23 | E-GEOD-36524 | biostudies-arrayexpress
TranscriptomicsGene expression data from renal preneoplastic lesions
Microarrays were used to analyse gene expression underlying early tumourigenesis in Eker rats. Distinct classes of up- and downregulated genes were identified in different preneoplasic lesion vs. microdissected normal (healthy) renal tubules. Laser capture microdissected renal basophilic atypical tu...
ORGANISM(S): Rattus norvegicus 
2010-02-28 | E-GEOD-10608 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors (mRNA)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcino- genesis. Here, we have used a humanized CAR/PXR mo...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60684 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors (miRNA)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcino- genesis. Here, we have used a humanized CAR/PXR mo...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60688 | biostudies-arrayexpress
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