Transcription profiling of rat liver response to genotoxic carcinogens at doses known to induce liver tumors in the 2-year rat bioassay - short term in vivo study

ABSTRACT: When applied in toxicological studies, the recently developed gene expression profiling techniques using microarrays, which brought forth the new field of toxicogenomics, facilitate the interpretation of a toxic compound?s mechanism of action. In this study, we investigated whether genotoxic carcinogens at doses known to induce liver tumors in the 2-year rat bioassay deregulate a common set of genes in a short-term in vivo study and, if so, whether these deregulated genes represent defined biological pathways. Rats were dosed with the four genotoxic hepatocarcinogens Dimethylnitrosamine [CAS:62-75-9;CHEBI:21778] (4 mg/kg/day), 2-nitrofluorene [CAS:607-57-8;CHEBI:1224] (44 mg/kg/day), Aflatoxin B1 [CAS:1162-65-8;CHEBI:2504] (0.24 mg/kg/day), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanon

INSTRUMENT(S): Agilent 2001 Bioanalyzer

ORGANISM(S): Rattus norvegicus

SUBMITTER: Heidrun Ellinger-Ziegelbauer 

PROVIDER: E-TOXM-16 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress