Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

ABSTRACT: For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposure to genotoxic (GTX) and non-genotoxic (NGTX) hepatocarcinogens and non-carcinogens (NC) in five liver-based in vitro models, namely conventional and epigenetically-stabilized cultures of primary rat hepatocytes, the human hepatoma-derived HepaRG and HepG2 cell lines and the human embryonic stem cell-derived hepatocyte-like cells hES-Heps are examined and compared. The global gene expression profiles of five commonly used liver-based in vitro systems are investigated, namely conventional cultur

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tatyana Doktorova 

PROVIDER: E-GEOD-40117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress