Discriminant for genotoxic and non-genotoxic carcinogens by differentially expressed gene profiling

ABSTRACT: The need for an efficient carcinogenicity test prompted this study, in which we used a microarray-based genomics approach, with a short-term in vivo model, in combination with insights from statistical and mechanistic analyses. We performed additional experiments to support the significance of the microarray results. Carcinogens were evaluated based on differences in the mechanisms involved in the response to genotoxic (GTX) carcinogens and non-genotoxic (NGTX) carcinogens. Microarray data were analyzed for 2 time points after treatment with the following 6 carcinogens. The analysis was performed using t-tests to compare the fold changes, and we selected differentially expressed genes (DEGs) and evaluated the reasons for differential expression in terms of cellular pathways and processes.

ORGANISM(S): Rattus norvegicus

SUBMITTER: seulji lee 

PROVIDER: E-GEOD-31307 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress