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TranscriptomicsSRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-49000 | biostudies-arrayexpress
UnknownExemestane versus anastrozole in postmenopausal women with early breast cancer: NCIC CTG MA.27--a randomized controlled phase III trial.
Not available
S-EPMC3612593 | biostudies-literature
UnknownTreatment-associated musculoskeletal and vasomotor symptoms and relapse-free survival in the NCIC CTG MA.27 adjuvant breast cancer aromatase inhibitor trial.
Not available
S-EPMC4289722 | biostudies-literature
UnknownHuman monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization.
Not available
S-EPMC3367042 | biostudies-literature
UnknownShort-rib polydactyly and Jeune syndromes are caused by mutations in WDR60.
Not available
S-EPMC3769922 | biostudies-literature
UnknownStructural basis of membrane bending by the N-BAR protein endophilin.
Not available
S-EPMC3319357 | biostudies-literature
UnknownInflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia.
Not available
S-EPMC6778500 | biostudies-literature
GenomicsA Genome-Wide Association Study in Patients Experiencing Musculoskeletal Adverse Events on NCIC CTG Trial MA.27 Evaluating Aromatase Inhibitors as Adjuvant Therapy in Early Breast Cancer. A Collaboration Between the NIH Pharmacogenetics Research Network and the RIKEN Yokohama Institute Center for Genomic Medicine.

Source of Patients
The source of the patients for this genome-wide case control study was MA.27, which was conducted as a multi-cooperative group effort under the auspices of the NCI Breast Cancer Intergroup of North America. The NCIC Clinical Trials Group (CTG) serves as the co...

phs000210.v1.p1 | EGA
UnknownThe inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
Not available
S-EPMC1523183 | biostudies-literature
UnknownModelling the evolution and spread of HIV immune escape mutants.
Not available
S-EPMC2987822 | biostudies-literature
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