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ProteomicsPeptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
Inhibiting protein-protein interactions via designed peptides is a suitable strategy to block the function of important proteins in cells. The Elongin BC heterodimer (ELOB/C) is involved in transcription elongation and protein turnover. It interacts with target proteins via a so-called BC-box to mod...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD038414 | Pride
Peptide inhibition Elongin bc Cancer Prc2 Epop 
GenomicsPeptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
PRJNA882408 | ENA
UnknownMolecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.
Not available
S-EPMC2949506 | biostudies-literature
UnknownEPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
Not available
S-EPMC5210178 | biostudies-literature
GenomicsEPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)
EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)
PRJNA307667 | ENA
UnknownThe Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Not available
S-EPMC317264 | biostudies-literature
TranscriptomicsEPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions that display both active and repressive chromatin properties. These regions exhibit low levels of gene expression, yet the mechanisms controlling these levels remain unknown. Here, we describe Elongin BC ...
ORGANISM(S): Mus musculus 
2016-11-21 | GSE79606 | GEO
TranscriptomicsPeptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
Inhibition of protein-protein interactions (PPIs) via designed peptides is an effective strategy to perturb their biological functions. The Elongin BC heterodimer (ELOB/C) binds to a BC-box motif and is essential for cancer cell growth. Here, we report a peptide that mimics the high-affinity BC-box ...
ORGANISM(S): Homo sapiens 
2023-06-24 | GSE213767 | GEO
GenomicsEPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (Elongin B KO)
Gene regulatory networks are pivotal for many biological processes. In mouse embryonic stem cells (mESCs) the transcriptional network can be divided into three functionally distinct modules: Polycomb, Core and Myc. The Polycomb module represses developmental genes, while the Myc module is associated...
ORGANISM(S): Mus musculus 
2016-11-17 | GSE79318 | GEO
GenomicsEPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape
EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape
PRJNA354401 | ENA
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