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ProteomicsEPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization
Polycomb repressive complex 2 (PRC2) mediates developmental gene repression as two classes of holocomplexes, PRC2.1 and PRC2.2. EPOP is an accessory subunit specific to PRC2.1, which also contains PCL proteins. Unlike other accessory subunits that collectively facilitate PRC2 targeting, EPOP was i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-20 | PXD072233 | Pride
GenomicsEPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)
EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)
PRJNA307667 | ENA
UnknownEPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity.
Not available
S-EPMC12485836 | biostudies-literature
GenomicsEPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
PRJNA1312105 | ENA
UnknownEPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
Not available
S-EPMC5210178 | biostudies-literature
ProteomicsAP-MS of EPOP in mouse embryonic stem cells
A Flag-tagged version of murine EPOP was expressed in mouse embryonic stem cells (ESCs) at near to endogenous levels and purified using an anti-FLAG affinity matrix.
ORGANISM(S): Mus musculus (Mouse) 
2016-12-13 | PXD005082 | Pride
Esc Prc2 Polycomb 
GenomicsEPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (RNA-Seq)
EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (RNA-Seq)
PRJNA1103785 | ENA
GenomicsEPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (ChIP-Seq)
EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (ChIP-Seq)
PRJNA1103786 | ENA
TranscriptomicsEPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape (EPOP KO)
Gene regulatory networks are pivotal for many biological processes. In mouse embryonic stem cells (mESCs) the transcriptional network can be divided into three functionally distinct modules: Polycomb, Core and Myc. The Polycomb module represses developmental genes, while the Myc module is associated...
ORGANISM(S): Homo sapiens Mus musculus 
2016-11-17 | GSE76536 | GEO
GenomicsEPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
The Polycomb repressive complex 2 (PRC2) establishes transcriptionally silent chromatin by catalyzing histone H3 lysine 27 trimethylation (H3K27me3). Although cofactors such as MTF2 and JARID2 are known to direct PRC2 to nucleation sites and stimulate its catalytic activity, the role of the PRC2-ass...
ORGANISM(S): Mus musculus 
2026-01-09 | GSE306783 | GEO
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