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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
TranscriptomicsGene expression data from undifferentiated mouse embryonal carcinoma cell strains (MOE430A and MOE430B)
Gene expression profiles of undifferentiated mouse embryonal carcinoma cell strains (P19, P19CL6, and 4 P19CL6 sublines) were obtained, using Affymetrix GeneChip Mouse Genome 430A and 430B. Heart diseases such as cardiac infarction damage cardiomyocytes and consequently lead to significant loss of t...
ORGANISM(S): Mus musculus 
2011-01-26 | E-GEOD-26875 | biostudies-arrayexpress
GenomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (ChIP-seq data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56450 | biostudies-arrayexpress
TranscriptomicsGene expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines
SOX2 is an oncogene and a core pluripotency transcription factor. SOX2 has multiple roles in various malignancies, in the maintainance of pluripotency and during various stages of embryonic development. Human embryonal carcinoma cells express SOX2 and the loss of this results in their differentiatio...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59234 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse F9 embryonal carcinoma cells exposed to differentiating agents (retinoic acid or trichostatin A) vs controls
F9 cells were exposed to two different differentiating agents (retinoic acid or trichostatin A both dissolved in 100% ethonal) for 24 hrs. Control cells were exposed to ethonal for 24hrs
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1437 | biostudies-arrayexpress
TranscriptomicsWhole-genome gene expression level changes in P19.6 mouse embryonal carcinoma cells compared to P19.6 cells treated for 48 hours with all-trans retinoic acid
Enhancers are developmentally-controlled transcriptional regulatory regions whose activities are modulated through histone modifications or histone variant deposition. Here, we show by genome-wide mapping that the newly discovered DNA modification 5-hydroxymethylcytosine (5hmC) is dynamically associ...
ORGANISM(S): Mus musculus 
2012-06-03 | E-GEOD-27334 | biostudies-arrayexpress
TranscriptomicsPhf19 knockdown effect on F9 embryonal carcinoma cells
PCL family protein Phf19/Pcl3 is one of the accessory components of the PRC2 core complex, and Phf19 is highly expressed in murine ES cells and an ES cell-like embryonic carcinoma cell line, F9 cells. Here we performed microarray analysis of embryonal carcinoma cell line F9 following Phf19 knockdown...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-42463 | biostudies-arrayexpress
TranscriptomicsGene-expression profile of human embryonic germ cells
Gene-expression profile of human embryonic germ cells (EGCs), primordial germ cells (PGCs), embryonal carcinoma cells (ECCs), pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs)
ORGANISM(S): Homo sapiens 
2018-06-28 | E-MTAB-6851 | biostudies-arrayexpress
GenomicsGenomic Screening of Testicular Germ Cell Tumors from Monozygotic Twins
Genomic screening was performed for one family containing MZ twins with testicular germ cell tumors, in order to define alterations associated with risk of tumor development. Copy number alterations were evaluated using array-CGH (4x44K, Agilent Technologies) in one seminoma and one embryonal carcin...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-GEOD-62779 | biostudies-arrayexpress
GenomicsDynamic hydroxymethylation of DNA marks differentiation-driven enhancers
This SuperSeries is composed of the following subset Series: GSE27334: Whole-genome gene expression level changes in P19.6 mouse embryonal carcinoma cells compared to P19.6 cells treated for 48 hours with all-trans retinoic acid GSE33067: Whole-genome mapping of MEIS1, TET1, H3K4me2 and H3K27ac in P...
ORGANISM(S): Mus musculus 
2012-06-03 | E-GEOD-27436 | biostudies-arrayexpress
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