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Proteomicsrotein expression in Nav1.7 embryonic null mice – mechanisms of compensation
Mice and humans who have lost the expression of functional sodium channel Nav1.7 are pain-free, but otherwise normal. This is the result of a loss of neurotransmitter release such as glutamate and Substance P from primary sensory neurons. The sensory neurons are otherwise normal apart from loss of n...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052513 | Pride
Two mechanisms of analgesia Drugs Pain Humans Autonomic side-effects Embryonic and adult nulls Sodium channels Mice Nav1.7 Opioid signalling 
TranscriptomicsThe connexin43-dependent transcriptome during brain development: importance of genetic background
Use of null mutant mice is a powerful way to evaluate the role of specific proteins in brain function. Studies performed on knockout mice have revealed some unexpected roles of the gap junction proteins (the connexins). Thus, analyses of gene expression in connexin43 (Cx43) null brains indicated tha...
ORGANISM(S): Mus musculus 
2012-04-13 | E-GEOD-37239 | biostudies-arrayexpress
UnknowneNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling.
Not available
S-EPMC10846539 | biostudies-literature
TranscriptomicsASD gene Bcl11a regulates subcellular RNA localization, associative circuitry, and social behavior
Precise, area-specific connectivity of interhemispheric callosal projection neurons (CPN) in the cerebral cortex is critical for sensory, associative, and behavioral functions. CPN circuitry, which connects and integrates the two cerebral hemispheres via the corpus callosum, is centrally implicated ...
ORGANISM(S): Mus musculus 
2025-08-15 | GSE211405 | GEO
GenomicsASD gene Bcl11a regulates subcellular RNA localization, associative circuitry, and social behavior
ASD gene Bcl11a regulates subcellular RNA localization, associative circuitry, and social behavior
PRJNA870113 | ENA
TranscriptomicsTranscription profiling of Drosophila homozygous CP190[1] 0 hour white prepupae (non tubby, red malpighian tubules) homozygous CP190[2] 0 hour white prepupae (non tubby, red malpighian tubules) homozygous red[1] e[1] 0 h white prepupae (source from which the mutated chromosome was obtained)
CP190 is a Drosophila protein of unknown function that exhibits cell cycle-specific localisation to the centrosome during mitosis and the nucleus during the interphase. CP190 associates with multiple sites on polytene chromosomes and its predicted amino acid sequence identifies four C2h2 zinc finger...
ORGANISM(S): Drosophila melanogaster 
2004-04-21 | E-FLYC-1 | biostudies-arrayexpress
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