Sort   by:  
 Page size 
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080827 | MassIVE
ProteomicsDiscovery of Klf2 Interactors in Mouse Embryonic Stem Cells by Immunoprecipitation-Mass Spectrometry Utilizing Exogenously Expressed Bait
Krüppel-like factor 2 (Klf2) is a DNA-binding transcription factor that regulates embryonic stem cell-specific gene expression. Transcription cofactors such as p300 acetyltransferases and Erk kinases interact with Klf2, providing an additional layer of transcription regulation in embryonic stem cell...
ORGANISM(S): Mus Musculus (mouse) 
2021-09-20 | PXD022123 | JPOST Repository
TranscriptomicsSingle Cell based genomewide gene expression analysis of murine bone-marrow derived Very Small Embryonic-Like Stem Cells (VSELs)
Recently, we identified a population of Oct4+Sca-1+Lin-CD45- very small embryonic-like stem-cells (VSELs) in adult tissues. Open chromatin structure of pluripotency genes and genomic imprinting-related epigenetic mechanisms maintain pluripotency and quiescence of VSELs, respectively. However, global...
ORGANISM(S): Mus musculus 
2011-12-21 | E-GEOD-29281 | biostudies-arrayexpress
TranscriptomicsExpression Profile of Embryonic Stem Cell Derived Serotonin Neurons
The rhesus embryonic stem cell line 366.4 differentiates into serotonin neurons. RNA was extracted from ESC colonies, embryoid body (Ebs), Neurospheres in selection (N1), Proliferating serotonin neurons (N2) and differentiating serotonin neurons (N3). RNA was labeled with Enzo biotin labelling kit a...
ORGANISM(S): Macaca mulatta 
2010-04-08 | E-GEOD-16168 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells (ESCs) differentiation into embyroid bodies (EBs
Stem cell differentiation is known to involve changes in RNA expression, but little is known about translational control during differentiation. We comprehensively profiled gene expression during differentiation of embryonic stem cells (ESCs) into embyroid bodies (EBs) by integrating conventional t...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-9563 | biostudies-arrayexpress
GenomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RRBS)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53507 | biostudies-arrayexpress
TranscriptomicsPedigreed Primate Embryonic Stem Cells Express Homogeneous Familial Gene Profiles
Pedigreed primate ESCs display homogeneous and reliable expression profiles. These similarities to mouse ESCs suggest that heterogeneities found among hESCs result from their disparate origins rather than intrinsic biological limitations with primate embryonic stem cells. Keywords: different nhpESC ...
ORGANISM(S): Macaca mulatta 
2008-04-14 | E-GEOD-7534 | biostudies-arrayexpress
GenomicsPolycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity
We report that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic stem cell (ESC) identity. In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcription and binds predominantly to promoters bearing active chromatin marks. Pcgf6 is expres...
ORGANISM(S): Mus musculus 
2016-07-28 | E-GEOD-84905 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray]
Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. However, the contribution of AS to the control of embryonic stem cell (ESC) pluripotency is not well understood. Here, we identify an evolutionarily conserved ESC-specifi...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-31948 | biostudies-arrayexpress
TranscriptomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RNA-Seq)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53506 | biostudies-arrayexpress
Sort   by:  
 Page size