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MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12489 | MetaboLights
MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12491 | MetaboLights
GenomicsThermotoga sp. EMP
Thermotoga sp. EMP Genome sequencing and assembly
PRJNA87045 | ENA
GenomicsExome-seq of Jak2VF erythroid progenitors cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls 17 weeks post transplantation
Exome sequencing of erythroid progenitors from Dnmt3a-Cas9-GFP+/- vs. emp-Cas9-GFP+/- controls.
ORGANISM(S): Mus musculus 
2018-10-29 | E-MTAB-7243 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Determination of differentially expressed genes in culture-derived hematopoietic stem cell progenitors (LSK) between Jak2VF-emp-Cas9 and Jak2VF-Dnmt3a-cas9.
ORGANISM(S): Mus musculus 
2018-10-29 | E-MTAB-6635 | biostudies-arrayexpress
TranscriptomicsATAC-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls 8 weeks post transplantation
Determination of chromatin accessibility in hematopoietic stem cell progenitors (LSK) of Jak2VF-emp-Cas9 and Jak2VF-Dnmt3a-Cas9 8 weeks post transplantation.
ORGANISM(S): Mus musculus 
2018-10-29 | E-MTAB-6649 | biostudies-arrayexpress
GenomicsSphingomonas paucimobilis strain:EMP 5-4
Sphingomonas paucimobilis strain:EMP 5-4 Genome sequencing
PRJNA1272276 | ENA
ProteomicsCombined effects of EMP and RF exposure on mouse hippocampus LC-MSMS
Recently, concerns about the combined effects of electromagnetic field (EMF) in daily living and occupational environment are rapidly growing. 4.9 GHz radiofrequency (RF) is commonly used in 5G telecommunication in daily life, EMP is common is occupational environment. Till now, the biological effec...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD038101 | Pride
Lc-msms Mouse Hippocampus 
GenomicsCitrobacter freundii strain:Cf-Emp
Citrobacter freundii strain:Cf-Emp Genome sequencing
PRJNA899443 | ENA
TranscriptomicsRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls 8 weeks post transplantation
Determination of differentially expressed genes from in vivo hematopoietic stem cell progenitors (LSK) in Jak2VF-emp-Cas9 and Jak2VF-Dnmt3a-Cas9 8 weeks post transplantation.
ORGANISM(S): Mus musculus 
2018-10-29 | E-MTAB-6644 | biostudies-arrayexpress
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