Sort   by:  
 Page size 
TranscriptomicsSingle-cell RNA sequencing for osteochondral fusions
We have developed a protocol to generate hPSC-derived osteochondral fusions that mimick embryonic long bone diaphysis. hPSCs were first differentiated to chondroprogenitors and osteogenesis-committed early chondrocytes. Then they were centrifuged together to genrate a fusion construct. After culture...
ORGANISM(S): Homo sapiens 
2025-02-21 | GSE275943 | GEO
ProteomicsDNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality
DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-30 | PXD067620 | Pride
Emrbyo Sprtn Dpc 
ProteomicsDNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality
DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-30 | PXD067624 | Pride
Emrbyo Sprtn Dpc 
ProteomicsDNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality
DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD067622 | Pride
Emrbyo Sprtn Dpc 
GenomicsExogenous estrogen exposure during preimplantation disrupts embryo transport and differentially alterns transcriptome in mouse oviduct and uterus
Exogenous estrogen exposure during preimplantation disrupts embryo transport and differentially alterns transcriptome in mouse oviduct and uterus
PRJNA1458286 | ENA
GenomicsSingle-cell RNA sequencing for osteochondral fusions
Single-cell RNA sequencing for osteochondral fusions
PRJNA1153927 | ENA
GenomicsHand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects [Spatial Transcriptomics]
Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects [Spatial Transcriptomics]
PRJNA1271041 | ENA
Sort   by:  
 Page size