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TranscriptomicsProcessing of Drosophila endo-siRNAs depends on a specific Loquacious isoform
Drosophila melanogaster expresses three classes of small RNAs, which are classified according to their mechanisms of biogenesis. MicroRNAs are ~22-23-nt, ubiquitously expressed small RNAs that are sequentially processed from hairpin-like precursors by Drosha/Pasha and Dcr-1/Loquacious complexes. Mic...
ORGANISM(S): Drosophila melanogaster 
2009-07-30 | E-GEOD-17171 | biostudies-arrayexpress
TranscriptomicsIdentification and analysis of transgene-derived endo-siRNAs in Drosophila Schneider cells by Solexa sequencing.
Colonization of genomes by a new selfish genetic element is detrimental to the host species and must lead to an efficient, repressive response. In vertebrates as well as in Drosophila, piRNAs repress transposons in the germ line while endogenous siRNAs take on this role in somatic cells. For endo-si...
ORGANISM(S): Drosophila melanogaster 
2009-09-13 | E-GEOD-16958 | biostudies-arrayexpress
TranscriptomicsTransposon defense by endo-siRNAs, piRNAs and somatic pilRNAs: Roles of Loqs-PD and R2D2
Transposable elements are a serious threat for genome integrity and their control via small RNA mediated silencing pathways is an ancient strategy. The fruit fly Drosophila melanogaster has two silencing mechanisms that repress TEs expression: endogenous siRNAs (esiRNAs or endo-siRNAs) and Piwi-inte...
ORGANISM(S): Drosophila melanogaster 
2015-01-19 | E-GEOD-45290 | biostudies-arrayexpress
TranscriptomicsEuchromatic transposon insertions trigger production of novel pi- and endo-siRNAs at the target sites in the Drosophila germline
The control of transposable element (TE) activity in germ cells provides genome integrity over generations. A distinct small RNA-mediated pathway utilizing Piwi-interacting RNAs (piRNAs) suppresses TE expression in gonads of metazoans. In the fly, primary piRNAs derive from so-called piRNA clusters,...
ORGANISM(S): Drosophila melanogaster 
2014-02-07 | E-GEOD-46105 | biostudies-arrayexpress
TranscriptomicsThe hub protein Loqs connects the miRNA and endo-siRNA pathways in mosquitos
Aedes aegypti mosquitoes vector several arboviruses of global health significance, including dengue viruses and chikungunya virus. RNA interference (RNAi) plays an important role in antiviral immunity, gene regulation and protection from transposable elements. Double-stranded RNA binding proteins (d...
ORGANISM(S): Aedes aegypti 
2015-04-08 | E-GEOD-65070 | biostudies-arrayexpress
ProteomicsIdentification of novel glycan modification on S-layer protein from Methanoculleus Marisnigri
Mass spectrometry and NMR were used to characterize the N- and O-glycan modifications expressed by Methanoculleus marisnigri, a mesophilic methanogen from the Order Methanomicrobiales. The S-layer protein was identified as a PGF-CTERM sorting domain-containing protein encoded by MEMAR_RS02690 and is...
ORGANISM(S): Methanoculleus marisnigri JR1 Archaea 
2023-03-23 | PXD030331 | Pride
O-glycosylation S-layer protein Archaea N-glycosylation Post-translational modification 
TranscriptomicsTranscript profiling in Paoenia ostii during chilling induced endo-dormancy release
To better understanding the genetic and physiological changes behind the dormancy process in tree peony, we performed customized cDNA microarray to investigate gene expression profiling in tree peony M-bM-^@M-^XFeng Dan BaiM-bM-^@M-^Y buds during chilling induced dormancy release. Endo-dormant tree ...
ORGANISM(S): Paeonia ostii 
2014-08-01 | E-GEOD-40004 | biostudies-arrayexpress
TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (piRNA and endo-siRNAs)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59254 | biostudies-arrayexpress
Transcriptomicshog1, slt2, rlm1, and msn2/4 mutants exposed to zymolyase
This SuperSeries is composed of the following subset Series: GSE9930: Wild type 3 hour exposure to zymolyase GSE9931: hog1 mutant 3 hour exposure to zymolyase GSE9932: slt2 mutant 3 hour exposure to zymolyase GSE9933: rlm1 mutant 3 hour exposure to zymolyase GSE9934: msn2/4 mutant 3 hour exposure to...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-19 | E-GEOD-12684 | biostudies-arrayexpress
ProteomicsAnalysis of SARS-CoV-2 S and human ACE2 protein by LC-MS
Analysis of deglycosylated N-linked glycopeptides for SARS-Cov-2 S and human ACE2 protein by LC-MS
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2020-09-09 | PXD019938 | Pride
Sars-cov-2 s ace2 deglycoslyation lc-ms 
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