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TranscriptomicsTranscription profiling of cells from four developmental stages of human endocrine pancreas to define genetic pathways that regulate endocrine pancreatic development
To define genetic pathways that regulate development of the endocrine pancreas, we generated transcriptional profiles of enriched cells isolated from four biologically significant stages of endocrine pancreas development: endoderm before pancreas specification, early pancreatic progenitor cells, end...
ORGANISM(S): Mus musculus 
2006-06-30 | E-CBIL-14 | biostudies-arrayexpress
GenomicsRNA-seq of sorted pancreatic endocrine progenitor cells
RNA-seq of sorted pancreatic endocrine progenitor cells
PRJNA630435 | ENA
TranscriptomicsEffect of Bicaudal C1 deletion on E13.5 mouse pancreatic mRNA profile
Bicaudal C1 KO embryonic pancreas develops cysts and has less endocrine progenitors after E14.5 (14.5 days after fertilization), while no defect is observed at E13.5. Bicaudal C1 is an RNA-binding protein. To understand the molecular mechanisms leading to both phenotypes, the mRNA expression profile...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-58833 | biostudies-arrayexpress
GenomicsRepression of Progenitor Programs Safeguards Pancreatic Endocrine Cell Identity
Repression of Progenitor Programs Safeguards Pancreatic Endocrine Cell Identity
PRJNA1262946 | ENA
TranscriptomicsTranscriptional regulation of endocrine cell differentiation by Insm1
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1^GFP/Pdx1^CFP HIGH [het/het] FACS sorted pancreatic cells (pre-beta cells) and Insm1^GFP/Pdx1^CFP LOW [het/het] cells (other endocrine progenitors) at E15.5 and E18.5. Comparison of Insm1 +/Pdx HIGH and Insm1 +/Pdx LO...
ORGANISM(S): Mus musculus 
2014-07-01 | E-MTAB-1929 | biostudies-arrayexpress
ProteomicsCharting endocrine progenitors across species and organs
Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are key targets for causal therapies for diabetes and obesity. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate disease mechanisms and develop im...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076279 | Pride
Diabetes Ngn3 Pancreas Proteomics Endocrine progenitor Β-cells 
ModelsdeBack2012 - Lineage Specification in Pancreas Development
deBack2012 - Lineage Specification in Pancreas Development This model of two neighbouring pancreas precursor cells, describes the exocrine versus endocrine lineage specification process. To account for the tissue scale patterns, this couplet model has been extended to hundreds of c...
2024-09-02 | BIOMD0000000435 | BioModels
TranscriptomicsTranscriptional Profiling of Ngn3-dependent endocrine progenitors and pre-beta cells
The goal of this study was to examine genetic networks that control endocrine cell type specification and differentiation. RNA-Seq technology was used to explore the gene expression profiles of pancreatic endocrine progenitor cells (at E10.5 and E15.5), impaired endocrine progenitor cells (at E10.5 ...
ORGANISM(S): Mus musculus 
2015-01-26 | E-MTAB-3272 | biostudies-arrayexpress
GenomicsSequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans
PRJNA580519 | ENA
TranscriptomicsTranscriptional profiling of Ngn3-dependent pancreatic endocrine differentiation at E15.5
This experiment used RNA-Seq technology to explore gene expression in mouse Ngn3^GFP/+ [het] FACS sorted pancreatic cells at E15.5 (commited endocrine progenitor cells) and in Ngn3^GFP/GFP [null] at E15.5 (defective endocrine progenitor cells). This experiment is designed to understand the gene expr...
ORGANISM(S): Mus musculus 
2015-10-01 | E-MTAB-3352 | biostudies-arrayexpress
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