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TranscriptomicsPlasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
Aims/hypothesis: Duct cells isolated from adult human pancreas can be reprogrammed to express islet beta cell genes by adenoviral transduction of the developmental transcription factor neurogenin3 (Ngn3). In this study we aimed to fully characterize the extent of this reprogramming and intended to i...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-30802 | biostudies-arrayexpress
ProteomicsIdentifying new interactors of NGN3 through IP-MS
NGN3 is a transcription factor whose transient expression during pancreatic development is vital for the generation of endocrine pancreatic cells, including beta cells. NGN3 stabilisation has been shown to induce exocrine-to-endocrine cell plasticity in the murine pancreas, making it a viable target...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-27 | PXD033691 | Pride
Ip-ms Ha-tag Ngn3 Hek293a Lc-ms/ms 
TranscriptomicsExpression data of Sox9+ and Ngn3+ mouse pancreas cells at different stages of development
Genes specific to Sox9+ pancreatic progenitors were identified by comparing the gene expression in embryonic and adult Sox9+ cells. We used microarray analysis to detail the global changes in gene expression as Sox9 positive embryonic pancreatic progenitors differentiatiate into adult ductal cells o...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-34060 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of inducible Ngn3 mouse embryonic stem cells
16 embryonic stem cell (ESC) samples (8 groups in duplicate) were processed for microarray analysis using the Affymetrix Mouse Genome 430 2.0 GeneChip. The samples included the parental Ainv15 ESC line (1) undifferentiated (Ainv15 ESC), (2) differentiated for 3 days as embryoid bodies (Ainv15 EB3) o...
ORGANISM(S): Mus musculus 
2007-06-29 | E-CBIL-29 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Ngn3 expressing cells and endocrine pancreatic cells from wild type and Ngn3 mutant animals at day 15 of embryonic development
The basic helix-loop-helix transcription factor Neurogenin3 (Ngn3/Neurog3) is expressed in endocrine progenitor cells in the embryonic mouse pancreas. Ngn3 controls endocrine cell fate decisions. Ngn3 deficient mice do not develop any pancreatic endocrine cells, including insulin producing beta cel...
ORGANISM(S): Mus musculus 
2009-12-03 | E-CBIL-48 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of undifferentiated and differentiated mouse embryonic stem cells in the presence or absence of neurogenin 3 (Ngn3) expression to better characterize the molecular events regulated by Ngn3 during development.
Expression of the proendocrine gene neurogenin 3 (Ngn3) is required for the development of pancreatic islets. In order to better characterize the molecular events regulated by Ngn3 during development, we have determined the expression profile of differentiating murine embryonic stem cells (mESCs) u...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3653 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pancreatic duct cell lines infected with Ngn3-expressing adenovirus
We have developed an in vitro model of Ngn3-dependent differentiation by infecting pancreatic duct cell lines with an Ngn3-expressing adenovirus. We used glass microarrays containing 18,000 mouse cDNAs and compared gene expression patterns in mPAC L20 cells infected with either AdCMV-gal (control) o...
ORGANISM(S): Mus musculus 
2006-07-25 | E-CBIL-15 | biostudies-arrayexpress
GenomicsTranscriptional response of NGN3 J2 enteroids
Transcriptional response of NGN3 J2 enteroids
PRJNA575547 | ENA
TranscriptomicsTranscriptional profiling of Ngn3-dependent pancreatic endocrine differentiation at E15.5
This experiment used RNA-Seq technology to explore gene expression in mouse Ngn3^GFP/+ [het] FACS sorted pancreatic cells at E15.5 (commited endocrine progenitor cells) and in Ngn3^GFP/GFP [null] at E15.5 (defective endocrine progenitor cells). This experiment is designed to understand the gene expr...
ORGANISM(S): Mus musculus 
2015-10-01 | E-MTAB-3352 | biostudies-arrayexpress
GenomicsTranscriptional response of NGN3 J2 enteroids.
Transcriptional response of NGN3 J2 enteroids.
PRJNA1118255 | ENA
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