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ProteomicsTransmembrane protein 184B (TMEM184B) promotes endolysosomal acidification through vesicular proton pump regulation
Disruption of endolysosomal acidification is a hallmark of several neurodevelopmental and neurodegenerative disorders. Impaired acidification causes accumulation of toxic protein aggregates and disrupts neuronal homeostasis, yet the molecular mechanisms regulating endolysosomal pH in neurons remain ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD064977 | Pride
Vatpase Endolysosomal acidification Tmem184b 
UnknownTMEM184B modulates endolysosomal acidification via the vesicular proton pump.
Not available
S-EPMC12377713 | biostudies-literature
UnknownImpaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes.
Not available
S-EPMC3718029 | biostudies-literature
TranscriptomicsEndolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised blood-brain barrier integrity
The neurovascular unit (NVU) is a complex multicellular structure that helps maintain cerebral homeostasis and blood-brain barrier (BBB) integrity. While extensive evidence links NVU alterations to cerebrovascular diseases and neurodegeneration, the underlying molecular mechanisms remain unclear. He...
ORGANISM(S): Danio rerio 
2024-09-01 | GSE270309 | GEO
GenomicsEndolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised blood-brain barrier integrity
Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised blood-brain barrier integrity
PRJNA1126173 | ENA
UnknownMurine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments.
Not available
S-EPMC2857745 | biostudies-literature
GenomicsEffect of lysosomal acidification on Grn knockout primary microglia transcriptome [HEX000747_MG]
Effect of lysosomal acidification on Grn knockout primary microglia transcriptome [HEX000747_MG]
PRJNA1136519 | ENA
UnknownPKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis.
Not available
S-EPMC12441718 | biostudies-literature
UnknownAntidepressant Sertraline Is a Broad-Spectrum Inhibitor of Enteroviruses Targeting Viral Entry through Neutralization of Endolysosomal Acidification.
Not available
S-EPMC8780434 | biostudies-literature
TranscriptomicsEffect of lysosomal acidification on Grn knockout primary microglia transcriptome [HEX000747_MG]
WT or Grn knockout primary mouse microglia were treated with endolysosomal acidifier rimeporide and bulk RNA-seq was performed.
ORGANISM(S): Mus musculus 
2026-07-20 | GSE272363 | GEO
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