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UnknownRegulation of Archease by the mTOR-vATPase axis.
Not available
S-EPMC9641670 | biostudies-literature
UnknownPAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes.
Not available
S-EPMC9114668 | biostudies-literature
UnknownPresenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.
Not available
S-EPMC4558203 | biostudies-literature
ProteomicsTransmembrane protein 184B (TMEM184B) promotes endolysosomal acidification through vesicular proton pump regulation
Disruption of endolysosomal acidification is a hallmark of several neurodevelopmental and neurodegenerative disorders. Impaired acidification causes accumulation of toxic protein aggregates and disrupts neuronal homeostasis, yet the molecular mechanisms regulating endolysosomal pH in neurons remain ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD064977 | Pride
Vatpase Endolysosomal acidification Tmem184b 
TranscriptomicsMaintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation
Purpose: In previous work, we found that iron supplementation to cells rescues impairment of cell viability and proliferation upon lysosomal dysfunction due to inhibition of the vATPase complex. The goal of this study is to characterize the transcriptomic changes (RNA-seq) upon Bafilomycin mediated ...
ORGANISM(S): Homo sapiens 
2019-12-06 | GSE141507 | GEO
UnknownGreenhouse test of spraying dsRNA to control the western flower thrips, Frankliniella occidentalis, infesting hot peppers.
Not available
S-EPMC10074877 | biostudies-literature
Transcriptomicsβ2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7
Lysosomal dysfunction is considered pathogenic in Alzheimer Disease (AD). Loss of Presenilin-1(PSEN1) function causing early onset AD impedes acidification via defective vATPase V0a1 subunit delivery to lysosomes. We report that isoproterenol and related β2-adrenergic agonists re-acidify lysosomes i...
ORGANISM(S): Mus musculus 
2020-02-29 | GSE136894 | GEO
UnknownThe TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex.
Not available
S-EPMC5932569 | biostudies-literature
UnknownCompensatory branching morphogenesis of stalk cells in the Drosophila trachea.
Not available
S-EPMC4460740 | biostudies-literature
UnknownThe Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase.
Not available
S-EPMC2720251 | biostudies-literature
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